V (D)J recombination - Wikipedia
V (D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B …
抗体库的基础——聊聊免疫球蛋白基因及重排 - 知乎
Ig类别转换 或称 同种型转换 是指一个B细胞克隆在分化过程中重链可变区基因片段（VDJ）保持不变，而按一定顺序与不同的CH基因片段分别发生重排。比较与不同CH基因片段重排后基因编 …
1.2.2 V (D)J重组的发生机制 - 哔哩哔哩
这种机制也被称为 12/23规则 (12/23 rule)。 V(D)J重组酶首先在单个12或23 RSSs上组装，产生一个信号复合体(SC)，诱导基因缺口的产生。 与对应RSS的联会(synapsis)可导致配对复合 …
The Mechanism and Regulation of Chromosomal V(D)J Recombination
2002年4月19日 · V (D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V (D)J recombination …
10X单细胞（10X空间转录组）转录组 + VDJ联合分析（12） …
2024年5月4日 · 资源摘要信息:"2021年3月举行的关于单细胞RNA-Seq数据分析中VDJ分析的高级主题研讨会，该研讨会专注于10x平台产生的单细胞RNA-Seq数据的VDJ分析。 该课程面向具 …
Running Cell Ranger vdj - Official 10x Genomics Support
In this tutorial, we will work with the Human B cells dataset from a Healthy Donor (1k cells). Watch a short video tutorial or follow the text instructions below. Open up a terminal window. You …
The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J ...
1996年4月5日 · V(D)J recombination requires a pair of signal sequences with spacer lengths of 12 and 23 base pairs. Cleavage by the RAG1 and RAG2 proteins was previously shown to …
Beyond the 12/23 Rule of VDJ Recombination Independent of the …
2005年5月15日 · The 12/23 rule prevents rearrangement of V or J genes within their own clusters and ensures the obligatory inclusion of a D segment during IgH gene recombination, because …
Recombination signal sequences restrict chromosomal V (D)J ...
2000年6月1日 · The 12/23 rule, which is mediated at the level of RAG-1/2 recognition and cutting 4,5, specifies that V(D)J recombination occurs only between a gene segment flanked by a 12 …
12.1 How to install and use VDJtools for immunome data
2016年9月29日 · It introduces the basic work flow of how to get information from your next...
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