V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B …

Recent genomewide analyses of lymphoid neoplasms have revealed V(D)J recombination-driven oncogenic events, and have intensified interest in the regulatory mechanisms responsible for …

V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA …

Apr 19, 2002 · V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination …

Mar 11, 2011 · V(D)J recombination, which assembles antigen receptor genes during lymphocyte development, is initiated when the recombination activating gene 1 (RAG1) and RAG2 …

VDJ recombination is the process by which T cells and B cells randomly assemble different gene segments-known as variable (V), diversity (D), and joining (J) genes-in order to generate …

This section briefly overviews the normal mechanism of V(D)J recombination (for more details, see references 8 and 9). The V(D)J recombinase recognizes conserved DNA sequence …

V(D)J recombination is a site-specific recombination reaction that occurs specifically in developing oocytes of vertebrates and plays a part in generating their vast repertoire of immunoglobulins …

Jul 11, 2018 · In this article, I will explain to you the structure of the antibody, the mechanism of VDJ recombination and the concept of antibody diversity. The present article will help you …

Jan 23, 2004 · V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable …