Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells. In analogy of the role of E-cadherin as major determinant for epithelial cell contact integrity, VE-cadherin is of vital importance for the maintenance and control …

VE-cadherin is essential for controlling endothelial monolayer permeability and angiogenesis. There are many mechanisms that regulate VE-cadherin including, modulating VE-cadherin activity through phosphorylation and controlling the amount of VE-cadherin available for engagement at adherens junctions at both the protein and mRNA level (Figure 2A).

2007年12月27日 · Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells. In analogy of the role of E-cadherin as major determinant for epithelial cell contact integrity, VE-cadherin is of vital importance for the maintenance and control of endothelial cell contacts.

The two major cadherins of endothelial cells are neural (N)-cadherin and vascular endothelial (VE)- cadherin. Despite similar level of protein expression only VE-cadherin is located at cell–cell contacts, whereas N-cadherin is distributed over the ...

VE-cadherin, also known as CDH5 or CD144, is a type II cadherin mainly expressed in endothelial adherens junctions. Therefore, most of the VE-cadherin studies have been related to its role in endothelial cells (see [54] for a recent review).

Vascular endothelial (VE)-cadherin, an endothelium-specific adhesion protein, is found in the junctions between endothelial cells (ECs). It’s crucial to maintain the homogeneity of ECs. Keeping and controlling the contact between ECs is essential.

This review will focus on Vascular Endothelial (VE)-cadherin, an endothelial-specific cell-cell adhesion protein of the adherens junction complex. VE-cadherin plays a key role in endothelial barrier function and angiogenesis, and consequently VE-cadherin availability and function are tightly regulated.

2011年4月22日 · Vascular endothelial cadherin (VE-cadherin), a divergent member of the type II classical cadherin family of cell adhesion proteins, mediates homophilic adhesion in the vascular endothelium.

Vascular endothelial cadherin (VE-cadherin or cadherin-5) is expressed specifically in endothelial cells, and mediates calcium-dependent homophilic binding at adherens junctions between cells (Suzuki et al., 1991; Lampugnani et al., 1992; Breier et al., 1996).

2014年2月18日 · Phosphorylation of the adhesion molecule VE-cadherin at tyrosine residues modulates the opening of endothelial junctions during inflammatory reactions. The replacement of two distinct residues in...