2010年9月1日 · Vascular endothelial growth factor (VEGF) is one of the most important angiogenic growth factors for tumor angiogenesis. Here, we sought to explore whether RNA interference (RNAi) targeting matrix metalloproteinase-2 (MMP-2) could disrupt VEGF-mediated angiogenesis in lung cancer. MMP-2 siRNA inhibi …

2015年1月1日 · MMP-2 expression showed a significant association with more invasive cancer stages (p < 0.001) and death (p < 0.041).VEGF-α expression correlated with a high TNM stage (p < 0.009), the degree of cell differentiation (p < 0.025) and patient death as a result of disease (p < 0.035).The Kaplan–Meier survival estimated that patients with strong staining for MMP-2 (log-rank x 2 = 34.09; p < 0. ...

【摘 要】目的 探讨基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)及血管内皮生长因子(VEGF)在结肠癌中的表达,并分析其与肿瘤转移的相关性.方法 86例经病理证实的结肠癌患者,采用免疫组化SP法检测MMP-2、MMP-9及VEGF在结肠癌组织及正常结肠组织中的表达,分析三者 ...

Purpose: Angiogenesis and tumor invasion are complex processes that are mediated by various proteins, such as vascular endothelial growth factor (VEGF-α) and the matrix-degrading enzymes metalloproteinase-2 and -9 (MMP-2, MMP-9). The aim of this study was to determine what roles MMP-2, MMP-9, and VEGF-α play in colorectal cancer (CRC) by correlating their expression levels with the cancer ...

2023年2月9日 · In tumor angiogenesis, MMP-2 and MMP-9 have been shown to be critical during the “angiogenic switch”. Since the majority of produced VEGF is sequestered in the ECM deposited by tumor and stromal cells, the proteolytic release of angiogenic factors from tissue matrix, mainly mediated by MMP-2 and MMP-9, is essential for in vivo induced ...

2012年4月1日 · In 1992, Deschemaeker et al noticed the influence of VEGF on inducing metalloproteinases expression, including MMP-2 and MMP-9, both connected with a cancer’s invasiveness, which stimulate angiogenesis through the degradation of the extracellular matrix, and the alternation of a phenotype to an angiogenic one [7,16,19,21,23,31]. These ...

Background: Gastric carcinoma is still a major leading cause of cancer death in East Asia. Since angiogenesis is a necessary condition for invasion and metastasis, its regulation is of essential significance. Materials and methods: Expressions of MMP-2, MMP-9 and VEGF were examined with microarray of gastric carcinoma tissue samples (n = 249) by immunostaining.

The expression levels of MMP-2 and VEGF are more in tumor cells as compared to their normal tissue counterparts in lung cancers. MMP-2 and VEGF have been implicated in angiogenesis and tumor progression. We show the mechanism involved in VEGF downregulation in MMP-2 inhibited lung cancer cells.

目的:本研究探讨vegf,mmp-2及血管生成在大肠癌发生,发展中的作用及相互关系,旨在了解大肠癌发生,发展及血管生成的机制,为大肠癌新的治疗途径——抗血管生成治疗 3 郑州大学切0二年硕士毕业论文veg厂,mmp 2在大肠癌中的表达及其与血管生成的关系 中,低分化大肠 ...

Matrix metalloproteinases (MMPs) are involved in extracellular matrix (ECM) remodeling during embryogenesis, wound healing and tumor development. Aberrant expressions and activation of MMP-2 and MMP-9 are examined as one of the major attributes acquired by tumor neoangiogenic markers including vascular endothelial growth factor (VEGF), basic growth factor (bFGF) and CD105-microvessel density ...