We discovered new PDGF:VEGFR2 interactions with PDGF-AA:R2 K D = 530 nM, PDGF-AB:R2 K D = 110 pM, PDGF-BB:R2 K D = 40 nM, and PDGF-CC:R2 K D = 70 pM. We computationally predict that cross-family PDGF binding could contribute up to 96% of VEGFR2 ligation in healthy conditions and in cancer.

血管内皮生长因子 (vegf) 是一种强效的生长和血管生成细胞因子。其会刺激内皮细胞的增殖和存活，促进血管生成和血管通透性。vegf 在血管化组织中表达，在正常和病理血管生成中起着重要作用。大量证据表明 vegf 对肿瘤转移和眼内新生血管内综合征的诱导作用。

This study also challenges the general view that VEGFs target mainly endothelial cells, whereas mesenchymal cells are targeted by PDGFs. Further challenge to the functional distinctions between PDGFs and VEGFs comes from findings that VEGF-C and PDGF-A both regulate oligodendrocyte development, however, through distinct receptors.

The vascular endothelial growth factor (VEGF) family of cytokines plays a key role in vasculogenesis, angiogenesis, and lymphangiogenesis. VEGF-A is the main member of this family, alongside placental growth factor (PlGF), VEGF-B/C/D in mammals, and VEGF-E/F in other organisms.

Learn about the members of the VEGF and PDGF protein families: their functions, tissue expression, receptor interactions, and how they are used in biomedical research.

血小板源性生长因子 PDGF家族与VEGF家族是血管生长因子的两个主要家族，进化关系近。 目前已知有四种PDGF基因：PDGF-A、PDGF-B、PDGF-C和PDGF-D。 4种基因产物以二硫键连接成同二聚体或异二聚体的形式分泌，也即PDGF-AA、PDGF-BB、PDGF-AB、PDGF-CC和PDGF-DD（图1）。 图1. PDGF家族成员及受体成员. 目前已知的PDGF受体有两种，即 PDGFRα 和 PDGFRβ，它们可以同时形成异二聚体和同二聚体（图1）。 配体结合促进受体二聚化、自身 …

2025年2月27日 · Angiogenesis, the formation of new vessels from existing vessels, is mediated by vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). Despite discoveries supporting the cross-family interactions between VEGF and PDGF families, sharing the binding partners between them makes it challenging to identify growth ...

2017年11月27日 · We discovered new PDGF:VEGFR2 interactions with PDGF-AA:R2 K D = 530 nM, PDGF-AB:R2 K D = 110 pM, PDGF-BB:R2 K D = 40 nM, and PDGF-CC:R2 K D = 70 pM. We computationally predict that...

1997年7月8日 · Vascular endothelial growth factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequence homology to platelet-derived growth factor (PDGF) and transforming growth factor β2 (TGF-β).

The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been shown to play major roles not only in physiological but also in most pathological angiogenesis, such as cancer. VEGF belongs to the PDGF supergene family characterized ...