VEGF调节肿瘤的血管生成，主要通过和其受体（VEGFR1、VEGFR2和VEGFR3）结合，从而激活细胞内信号通路；VEGFR和VEGF蛋白结合后，其胞内信号转导区的酪氨酸随即发生磷酸化，从而激活细胞内信号通路，最终导致血管内皮细胞的生长、增殖和成熟，新生血管的生成。 图1.VEGF家族不同成员与不同类型的VEGF受体结合[1] VEGF 家族的生物活性通过与两类受体结合而介导：具有酪氨酸激酶活性的受体和不具有酪氨酸激酶活性的受体。 第一类受体由三种结 …

血管内皮生长因子 受体3 (VEGFR-3，VEGF-R3，VEGFR3)，又名Flt-4，是血管内皮生长因子C和D的 酪氨酸激酶受体，被认为参与淋巴管生成和淋巴管内皮的维持。 该基因突变导致遗传性IA型淋巴水肿。 一些研究表明VEGF-C、VEGF-D、 VEGFR-3 的表达与血管侵犯、淋巴管和淋巴结的参与之间呈正相关关系。 VEGF-C/VEGF-D/VEGFR3信号通路可为前列腺、乳腺、胃、肺、非小细胞肺malignant tumor等的抗淋巴管生成治疗提供靶点。 知乎，中文互联网高质量的问答社区和 …

VEGF-A regulates angiogenesis and vascular permeability by activating 2 receptors, VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk1 in mice). On the other hand, VEGF-C/VEGF-D and their receptor, VEGFR-3 (Flt-4), mainly regulate lymphangiogenesis.

Endothelial cell growth media containing VEGF, VEGF-C, and FGF basic elicited proliferation of non-adherent CD34 + CD133 + VEGF R3 + cells, which differentiated into adherent cells that ceased expressing CD133. 9 These new findings describe the existence of a unique stem cell population that may contribute to both embryonic and adult ...

2003年10月17日 · V5 epitope-tagged kinase-dead VEGFR-3 (R3-KD) was expressed alone or in combination with either wild type VEGFR-3 or wild type VEGFR-2 in 293T cells. Cells stimulated with VEGF-C were lysed, and R3-KD was immunoprecipitated …

2014年12月18日 · VEGF-C activates AKT signaling via formation of VEGFR3/VEGFR2 complex, whereas ERK is activated by VEGFR3 homodimer. Neuropilin 1 and vascular endothelial phosphotyrosine phosphatase are involved in regulation of VEGFR3 signaling.

The enzyme domains of VEGF receptor 1 (VEGF R1, also known as Flt-1), VEGF R2 (also known as KDR or Flk-1), and VEGF R3 (also known as Flt-4) are divided by an inserted sequence (see figure 1). Endothelial cells also express additional VEGF receptors, Neuropilin-1 and Neuropilin-2.

血管内皮生长因子（vegf）是内皮细胞的主要生长因子。kdr基因编码vegf的两个受体之一。该受体称为激酶插入结构域受体，是iii型受体酪氨酸激酶。它是vegf诱导内皮细胞增殖、生存、迁移、管状形态发生和萌发的主要介质。

Vascular Endothelial Growth Factors (VEGFs) and their receptors (VEGF-Rs) are important regulators for angiogenesis and lymphangiogenesis. VEGFs and VEGF-Rs are not only expressed on endothelial cells but also on various subtypes of solid tumors and leukemias contributing to the growth of the malignant cells.

VEGFR-3 /FLT4 蛋白是 VEGFC 和 VEGFD 的酪氨酸蛋白激酶受体，在成人淋巴管生成和胚胎血管发育中至关重要。 它促进内皮细胞功能、血管生成，并形成正反馈回路，增加 VEGFC 的产生。