Vascular endothelial growth factor (VEGF, / v ɛ dʒ ˈ ɛ f /), originally known as vascular permeability factor (VPF), [1] is a signal protein produced by many cells that stimulates the …

Unlike members of the PDGFR family that strongly stimulate the PI3K-Akt pathway toward cell proliferation, VEGFR-2, the major signal transducer for angiogenesis, preferentially utilizes the …

2019年3月7日 · The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development …

2016年7月27日 · Vascular endothelial growth factor receptor (VEGFR) signalling is tightly regulated at different levels: ligand and receptor expression, the presence of...

Canonical VEGF signaling through VEGF-R1/R2 (with R2 being the dominant signaling receptor) regulates the activities of several kinases and ultimately guides cell proliferation, migration, …

血管内皮生长因子 （vegf）是成人中健康和疾病期间血管发育和血液及淋巴管功能的主要调节因子。vegf由几种细胞类型如成纤维细胞，炎性细胞和许多肿瘤细胞产生，通常响应于通过hif-1a …

vegf 配体与其同源膜结合受体结合会诱发 vegf 信号传导，从而激活多个下游通路。 VEGF 信号传导级联反应包括： Ras/MAPK 通路，调控细胞增殖与基因表达

2023年7月25日 · Among these, vascular endothelial growth factor A (VEGFA; also known as VEGF) and its two tyrosine kinase receptors, VEGFR1 and VEGFR2, represent a key...

VEGF signaling is increasingly recognized for its roles outside of the vascular system, notably during neural development, and blood vessels regulate epithelial branching morphogenesis. …

17 小时之前 · Vascular Endothelial Growth Factor (VEGF) signaling is crucial for the normal development and maintenance of blood vessels. Under healthy conditions, VEGF ensures …