
mTORC1 drives HIF-1α and VEGF-A signalling via multiple
2014年6月16日 · By blocking mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signalling, rapalogue efficacy is likely to occur, in part, through suppression of hypoxia-inducible factors (HIFs) and...
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling …
2009年2月24日 · Vascular endothelial growth factor (VEGF)-A inhibitors exhibit unseen high responses and toxicity in recurrent epithelial ovarian cancer suggesting an important role for the VEGF/VEGFR pathway....
The mTOR/AP-1/VEGF signaling pathway regulates vascular …
2016年8月8日 · In order to clarify the role of the mTOR signaling pathway in vascular endothelial cell proliferation, we used siRNA and overexpression vectors to down- or upregulate AP-1, mTOR, and VEGF in rat vascular endothelial cells (RAEC) and measured resulting changes in mRNA expression, protein levels, and cell proliferation.
mTOR/4EBP1/HIF-1α/VEGF信号通路在哮喘小鼠肺组织中的表达及 …
真核生物始动因子4E结合蛋白1(eukaryote initiating factor 4E binding protein 1,4EBP1)是mTOR下游的一个重要靶蛋白,激活后可促进包括缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)、血管内皮生长因子(vascular endothelial growth factor,VEGF)在内的调节细胞生长 …
The mTOR/AP-1/VEGF signaling pathway regulates vascular
2016年8月16日 · Vascular restenosis is a common adverse event following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). The atypical Ser/Thr protein kinase mammalian target of rapamycin (mTOR) plays an important role in cell differentiation and apoptosis.
Substrate stiffening promotes VEGF-A functions via the PI3K/Akt/mTOR …
2022年1月1日 · Here, we report an underlying role for the PI3K/Akt/mTOR signaling pathway. This pathway is activated on stiffer substrates, is amplified by VEGF-A stimulation, and correlates with enhanced endothelial cell (EC) proliferation, contraction, pro-angiogenic secretion, and capillary-like tube formation.
Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes …
2019年12月5日 · In the present article we utilized two entirely different approaches: targeting mammalian target of rapamycin (mTOR) pathway that is known to be involved in VEGF synthesis, and disruption of...
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling …
2009年3月3日 · Vascular endothelial growth factor (VEGF)-A inhibitors exhibit unseen high responses and toxicity in recurrent epithelial ovarian cancer suggesting an important role for the VEGF/VEGFR pathway. We studied the correlation of VEGF signalling and AKT/mTOR signalling.
A VEGFB-Based Peptidomimetic Inhibits VEGFR2-Mediated PI3K/Akt/mTOR …
2023年6月20日 · Vascular endothelial growth factor receptor 2 (VEGFR2) mediates VEGFA signaling mainly through the PI3K/AKT/mTOR and PLCγ/ERK1/2 pathways. Here we unveil a peptidomimetic (VGB3) based on the interaction between VEGFB and VEGFR1 that unexpectedly binds and neutralizes VEGFR2.
Substrate stiffening promotes VEGF-A functions via the PI3K/Akt/mTOR …
2022年1月1日 · Here, we report an underlying role for the PI3K/Akt/mTOR signaling pathway. This pathway is activated on stiffer substrates, is amplified by VEGF-A stimulation, and correlates with enhanced endothelial cell (EC) proliferation, contraction, pro-angiogenic secretion, and capillary-like tube formation.