2020年9月1日 · Integrated analysis of transcriptome-wide m 6 A-seq and mRNA-seq analysis identified the glutamine transporter SLC1A5 as an FTO target that promotes metabolic …

2020年8月19日 · Here we report a synthetic lethal interaction between the epitranscriptomic modifier FTO and the tumor suppressor VHL. Notably, FTO inhibition reduced the growth of …

2024年9月27日 · VHL是ccRCC中最重要的肿瘤抑制因子，VHL的Co-IP实验发现VHL与METTL3、METTL14和WTAP相互作用 (图1F)。 METTL3或METTL14的Co-IP实验也证实了其与VHL相 …

何川与陈建军教授的脚步并未停留在Cell的研究上，近日，他们联手在Molecular Cell发表研究：Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and …

2022年11月1日 · Some studies demonstrated that decreased FTO expression was associated with aggressive clinical features and shorter overall survival in clear cell RCC (ccRCC) …

Genetic inactivation of FTO using multiple orthogonal approaches revealed that FTO inhibition selectively reduces the growth and survival of VHL-deficient cells in vitro and in vivo. Notably, …

Using this approach, we identified a synthetic lethal interac-tion between VHL and the m6A RNA demethylase FTO in renal cell carcinoma. MiSL identified FTO as a synthetic lethal partner of …

2024年11月4日 · In clear cell renal cell carcinoma (ccRCC), for example, FTO loss has been shown to limit glutamine consumption and suppress the survival of VHL-deficient cells, in part …

2024年4月15日 · Whether VHL regulates FTO protein’s function and its underlying mechanism remain to be investigated. Our study further demonstrates that VHL depletion results in altered …

2020年9月1日 · Here we report a synthetic lethal interaction between the epitranscriptomic modifier FTO and the tumor suppressor VHL. Notably, FTO inhibition reduced the growth of …