Interaction with p53 explains a pro-proliferative function for VHL …
We found that VHL interacts with p53, preventing its tetramerization, promoter binding and expression of its target genes p21, PUMA, and Bax. VHL limited the decrease in proliferation …
VHL and p53: Tumor Suppressors Team Up to Prevent Cancer
2006年5月19日 · In a recent issue of Molecular Cell, Roe et al. (2006) report that the von Hippel-Lindau (VHL) protein is a positive regulator of p53, thus providing insight into the mechanisms …
p53 Stabilization and Transactivation by a von Hippel-Lindau Protein
2006年5月5日 · We demonstrated that pVHL enhances p53 transcriptional activity and upregulates p53-downstream genes p21 and Bax, which ultimately lead to RCC cell cycle …
综述｜E3连接酶配体｜VHL在PROTACs研究中的近五年进展
vhl是 cullin 2 ring-vhl e3连接酶的底物识别亚基，参与泛素-蛋白酶体系统，主要功能是降解缺氧诱导因子α亚基（ hif-α ），发挥肿瘤抑制作用。基于vhl与hifs的相互作用，开发出了蛋白水解靶 …
VHL and p53: Tumor Suppressors Team Up to Prevent Cancer In a recent issue of Molecular Cell, Roe et al. (2006) re-port that the von Hippel-Lindau (VHL) protein is a pos-itive regulator …
The positive regulation of p53 by the tumor suppressor VHL
Recently, we found that pVHL directly associates and positively regulates the tumor suppressor p53 by inhibiting Mdm2-mediated ubiquitination, and by subsequently recruiting p53-modifying …
VHL/TP53/TSC1基因突变驱动的肾透明细胞癌精准治疗分析 - 知乎
TP53为著名的抑癌基因，是细胞周期相关基因，通过调控细胞周期相关蛋白的合成在细胞增殖和凋亡方面发挥重要的作用。 此基因突变，通常会影响PFS与OS，是肾癌的一个不良预后 。 …
VHL and p53: Tumor Suppressors Team Up to Prevent Cancer
2006年5月19日 · VHL interacts with p53, via its α domain, and with the proteins ATM and p300, which also interact with p53, thus forming a stable complex that responds to genotoxic stress …
VHL missense mutations in the p53 binding domain show …
We hypothesized that VHL missense mutations occurring in the p53 binding domain of pVHL lead to deficient p53 transactivation and/or promote HIF1α and HIF2α accumulation, thus impacting …
Interaction with p53 explains a pro-proliferative function for VHL in ...
2020年7月28日 · VHL and p53 physically interact and VHL inhibits p53 activity by limiting the formation of p53 tetramers. VHL attenuates the expression of p53 target genes in response to …