VKORC1 gene - MedlinePlus
The VKORC1 gene provides instructions for making a vitamin K epoxide reductase enzyme. The VKORC1 enzyme is made primarily in the liver. It spans the membrane of a cellular structure called the endoplasmic reticulum, which is involved with protein processing and transport.
VKORC1 Gene - GeneCards | VKOR1 Protein | VKOR1 Antibody
2024年12月10日 · VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) is a Protein Coding gene. Diseases associated with VKORC1 include Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2 and Coumarin Resistance .
Warfarin Therapy and VKORC1 and CYP Genotype - Medical …
2012年3月8日 · The VKORC1 gene encodes the vitamin K epoxide reductase enzyme, which catalyzes the rate-limiting step in vitamin K recycling (converting vitamin K epoxide to vitamin K). This enzyme is also the drug target for warfarin.
VKORC1 Pharmacogenomics Summary - PMC - PubMed Central …
The VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1, 2]. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues [3].
VKORC1 vitamin K epoxide reductase complex subunit 1
2024年11月3日 · Gene ID: 79001, updated on 3-Nov-2024. This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane.
Mutations in VKORC1 cause warfarin resistance and multiple
2004年2月5日 · VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain. Overexpression of wild-type VKORC1, but not VKORC1 carrying the VKCFD2 mutation, leads to a...
VKORC1 vitamin K epoxide reductase complex subunit 1 [Homo …
2024年3月5日 · This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane.
Mutations in VKORC1 cause warfarin resistance and multiple ... - PubMed
2004年2月5日 · Here we identify, by using linkage information from three species, the gene vitamin K epoxide reductase complex subunit 1 (VKORC1), which encodes a small transmembrane protein of the endoplasmic reticulum. VKORC1 contains missense mutations in both human disorders and in a warfarin-resistant rat strain.
Mutations in the VKORC1 Gene Cause Warfarin Resistance, …
2004年11月16日 · Mutations in the VKORC1 gene are causative for the hereditary conditions of VKCFD2, warfarin resistance and also warfarin sensitivity. Our findings may provide a basis for a rational design of novel anticoagulants targeting VKOR in the future.
VKORC1 Gene: The Role in Warfarin Therapy - ClarityX DNA
2024年8月5日 · Understanding the VKORC1 gene helps ensure that warfarin therapy works well and keeps the risk of dangerous reactions low. Genetic testing for variations in the VKORC1 gene helps doctors determine the optimal warfarin dosage for an individual.
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