2017年9月8日 · Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV.

2016年2月9日 · Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change.

2018年3月12日 · Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV. Here we report two crystal structures of VSV G in complex with two distinct cysteine-rich domains (CR2 and...

2015年7月16日 · Our understanding of RNA synthesis in NNS RNA viruses comes principally from studies of vesicular stomatitis virus (VSV)—an enveloped, bullet-shaped, rhabdovirus, closely related to rabies virus. VSV causes an acute disease of livestock.

Vesicular Stomatitis Virus (VSV) (PDB ID: 2J6J) is a virus in the Rhabdoviridae family. It carries its genetic information in the form of a single stranded minus sense RNA. It is enveloped, bullet shaped and 175 nm in length and 65 nm in width1.

PubMed Abstract: Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV.

2023年5月18日 · Our first targeted VSV (VSV-Sindbis-single chain antibody [SCA]-erbb2) replaced the native VSV-G glycoprotein (gp) with a binding-defective recombinant Sindbis virus (SV) gp (10) expressing a single chain antibody that …

2017年9月11日 · Vesicular stomatitis virus (VSV) is an oncolytic rhabdovirus and its glycoprotein G is widely used to pseudotype other viruses for gene therapy. Low-density lipoprotein receptor (LDL-R) serves as a major entry receptor for VSV.

2024年3月12日 · In the present study, we sought to develop a liver-targeted LV by engineering the envelope of lentivirus to facilitate targeted delivery of IDOL-shRNA (short hairpin RNA) to liver to more effectively ameliorate hypercholesterolemia and atherosclerosis (Figure 1), while also providing a potential lentivirus delivery system for liver-targeted tran...

2019年11月22日 · Identification of a pH-Sensitive Switch in VSV-G and a Crystal Structure of the G Pre-fusion State Highlight the VSV-G Structural Transition Pathway. VSV fusion machinery, like that of many other enveloped viruses, is triggered at low pH in …