2022年9月6日 · Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum inactivation of VSV-G pseudotyped vectors is a significant challenge for in vivo gene delivery.

Lentiviral tropism is determined by the ability of the viral envelope protein to interact with receptors at the host cell surface. The VSV-G envelope protein is commonly used in lentiviral particle production because it confers broad tropism over a range of species and cell types.

2018年7月13日 · Vesicular stomatitis virus G (VSV G) protein is a typical type III viral fusion protein. To study the mechanism of VSV G protein mediated membrane fusion, we set up a cell-cell fusion system in...

2025年2月12日 · Vesicular stomatitis virus glycoprotein G (VSV-G) is crucial in the viral life cycle, mediating entry into host cells and initiating infection. Understanding its structure and function is essential for developing antiviral strategies and enhancing gene therapy approaches.

2025年1月9日 · Explore the versatile roles of VSV G protein in viral entry, vaccine development, and gene therapy applications. The vesicular stomatitis virus (VSV) G protein is a key component of the viral envelope, essential for the virus’s ability to infect host cells.

2025年1月9日 · Explore the structure and function of VSV-G glycoprotein and its innovative applications in gene therapy and vaccine development. The VSV-G glycoprotein is a component of the vesicular stomatitis virus, playing a role in viral …

Vesicular stomatitis virus glycoprotein G (VSV-G) belongs to a new class of viral fusion proteins (Class III). The structure of VSV-G has been solved in two different conformations and fusion is known to be triggered by low pH.

We have previously shown that vesicles containing the spike glycoprotein of the vesicular stomatitis virus (VSV-G) can associate efficiently with immature, non-infectious, envelope-deficient retrovirus-like particles assembled by packaging cells to produce infectious, pseudotyped viruses in cell-fre …

2013年1月31日 · Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum inactivation of VSV-G...

We propose that VSV-G could be the ideal prototype for such chimaeric viral proteins. VSV-G is one of the most fusiogenic viral proteins identified and can be incorporated into many enveloped viruses, which can then efficiently infect a wide array of cells.