2014年12月12日 · The ventral tegmental area (VTA) in the brain’s reward circuitry is composed of a heterogeneous population of dopamine, GABA, and glutamate neurons that play important roles in mediating mood-related functions including depression.

2006年6月15日 · The objective of this review is to summarize the growing evidence for a role of the NAc, and its dopaminergic inputs from the VTA, in the regulation of mood and motivation under normal conditions, and in mediating many of the prominent behavioral abnormalities seen in depression and other mood disorders.

2019年6月15日 · Recent evidence shows that ventral tegmental area (VTA) dopamine neurons undergo circadian rhythmicity in activity. Evidence also implicates a role for dopaminergic areas in regulating sleep-wake cycle. This review provides a potential role of dopamine in linking mood disorders, circadian rhythms and sleep-wake cycle.

These studies demonstrate that the signaling pathways associated with VTA BDNF play an essential role in mood disorders, and critically influence susceptibility vs. resiliency to stressors. While BDNF modulation of VTA dopamine transmission is an important outcome of these intracellular signaling pathways, it is likely that such neurotrophin ...

The best characterized reward circuit in the brain comprises dopaminergic neurons in the ventral tegmental area (VTA) that project to the nucleus accumbens (NAc), which is part of the ventral striatum. The principal neurons of the NAc are GABAergic medium spiny neurons (MSNs).

2024年8月22日 · This remarkable neural ensemble, known as the ventral tegmental area (VTA), plays a pivotal role in our brain’s reward system and serves as a crucial hub for dopamine production. Nestled deep within the midbrain, the VTA acts as a conductor, directing the intricate interplay of neurotransmitters that influence our motivations, emotions, and ...

2025年3月10日 · Taken together, the loss-of-function modulation suggested a pivotal role of VTA-vHPC projection in maintaining the mood balance of naïve mice. Reversal of comorbid depressions by phasic activation of VTA DA-vHPC projection. As 91.7% of vHPC-projecting VTA neurons are DAergic, we investigated whether the anti-depressant function of the VTA-vHPC ...

2014年12月12日 · The ventral tegmental area (VTA) in the brain's reward circuitry is composed of a heterogeneous population of dopamine, GABA, and glutamate neurons that play important roles in mediating mood-related functions including depression. These neurons project to different brain regions, including the nucl …

2020年6月17日 · Acute inhibition or chronic lesioning of VTA Vgat neurons elevates mood. We assessed mood-related behaviors using TST, FST, SPT, and the elevated plus maze.

2024年1月3日 · Here, we identify a reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the ventral tegmental area (VTA) that mediates mutual exacerbation between hyperalgesia and...