Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion.It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic–uremic syndrome. [5]

Feb 20, 2023 · Von Willebrand factor (vWF) is a glycoprotein crucial to primary hemostasis through platelet and subendothelial collagen adhesion and the intrinsic coagulation cascade through factor VIII stabilization. It resides in the plasma, subendothelial matrix, and storage granules within endothelial cells and platelets.[1] vWF is a multimer composed of repeating subunits that create several binding ...

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Von Willebrand disease (VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.It is known to affect several breeds of dogs as well as humans.

Oct 26, 2021 · Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn't clot properly. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn't perform as it should.

(See also Overview of Platelet Dysfunction.). Von Willebrand factor (VWF) is synthesized and secreted by vascular endothelium to form part of the perivascular matrix. Von Willebrand factor promotes the platelet adhesion phase of hemostasis by binding with a receptor on the platelet surface membrane (glycoprotein Ib/IX), thus connecting the platelets to the vessel wall.

Aug 1, 2024 · Von Willebrand factor (VWF) is a protein crucial to the blood clotting process. If you don’t have enough of this protein, or if it doesn’t work as it’s supposed to, you may have von ...

VWF structure. (A) Graphic representation of the VWF monomer with its different domains and their binding ligands. Note that the D1 and D2 domains (propeptide) are cleaved upon released of VWF from the endothelial cell.

A number of transient clinical conditions can raise the vWF levels of individuals with congenital deficiency into the normal range. 8,9 vWF is an acute phase reactant and levels can increase due to stress, inflammation, acute infection, physical exercise, and following surgery. 8,9 Levels can also increase with estrogen administration for contraception or hormone replacement. 8,9 …

Von Willebrand factor (VWF) is a plasma glycoprotein best known for its crucial hemostatic role in serving as a molecular bridge linking platelets to subendothelial components following vascular injury. In addition, VWF functions as chaperone for coagulation factor VIII. In …