Functional vWF serves to protect factor VIII from proteolytic degradation and effectively increases its half-life fivefold. 8,9 Effective factor VIII binding is not dependent on the presence of large …

Von Willebrand disease (VWD) is a congenital bleeding disorder caused by a deficiency of von Willebrand factor (VWF) and typically characterized by mild mucosal bleeding. VWF plays …

2018年12月22日 · Von Willebrand factor (VWF) testing is used to investigate excessive or recurrent bleeding episodes or a personal or family history of excessive bleeding. Testing is …

2010年7月15日 · This test is used to screen and diagnose von Willebrand factor (vWF) deficiency. 6,8-10. If the patient's hematocrit exceeds 55%, the volume of citrate in the collection tube …

The vWf activity (ristocetin cofactor) assay reflects the effectiveness of the patient vWF in supporting platelet adhesion. A measure of factor VIII activity helps to determine if the vWF …

2009年12月1日 · Von Willebrand disease (VWD) encompasses a group of inherited bleeding disorders related to qualitative or quantitative defects of von Willebrand factor (VWF),...

Order in conjunction with von Willebrand Factor Antigen (0030285) and Factor VIII, Activity (0030095) as part of initial workup for suspected von Willebrand disease (VWD). Also useful …

The diagnosis or exclusion of any type of von Willebrand disease should never be based solely on the VWF activity result. This test should always be interpreted in conjunction with a group of …

Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating …

Laboratory testing for the VWF-related disorders requires assessment of both VWF level and VWF activity, the latter requiring multiple assays because of the many functions carried out by …