2014年2月4日 · The vacuole, together with the plasma membrane, is the most distal point of the secretory pathway, and many vacuolar proteins are transported from the ER through intermediate compartments.

The primary pathway of ER bodies ending with the autophagic sequestration in the vacuole constitutes an ERvt pathway that has parallel functions to the cytoplasm-vacuole (lysosomal)-trafficking (Cvt) pathway described in yeast and that also apparently exists in animal cells.

2014年2月4日 · The endoplasmic reticulum (ER) represents the gateway for intracellular trafficking of membrane proteins, soluble cargoes and lipids. In all eukaryotes, the best described mechanism of exiting the ER is via COPII-coated vesicles, which transport both membrane proteins and soluble cargoes to the cis -Golgi.

2020年1月1日 · In yeast, contact sites between the perinuclear ER (nuclear envelope) and the vacuole, namely the nucleus-vacuole junction (NVJ), are formed through the interaction of the ER membrane protein Nvj1 with Vac8, a palmitoylated vacuolar protein [95].

The conventional transport of proteins to the vacuole involves COPII-mediated ER-exit and the passage through several inter-mediate steps and compartments. Hence, the vacuole, together with the plasma membrane, may be seen as the most distal point of the secretory pathway.

2017年8月18日 · Even if the lumen of the secretory route compartments (ER, Golgi apparatus, trans -Golgi network, vacuole, etc.) is clearly different from the extracellular space, when a protein is translocated across the ER membrane to traffic along the secretory route, it leaves the cytoplasm and enters a type of ‘external space’.

2014年4月8日 · Trafficking of proteins from the endoplasmic reticulum (ER) to the vacuole is a fundamental process in plants, being involved both in vacuole biogenesis as well as with plant growth and response to environmental stresses.

2016年3月8日 · Here the site of contact between the ER and vacuole is known as the Nuclear ER (nER) Vacuolar Junction (NVJ), and comprises a ˜200–500 nm long patch-like strip juxtaposed between the outer nuclear envelope (continuous with the peripheral ER) and vacuole surface.

内质网 (ER) 代表细胞内运输膜蛋白、可溶性货物和脂质的途径。 在所有真核生物中，最好描述的退出 ER 的机制是通过 COPII 包被的囊泡，它将膜蛋白和可溶性货物运输到顺式高尔基体。

2014年2月4日 · The vacuole, together with the plasma membrane, is the most distal point of the secretory pathway, and many vacuolar proteins are transported from the ER through intermediate compartments.