2007年10月2日 · Elevated cardiac troponin-I (cTnI) levels have been demonstrated in serum of patients without acute coronary syndromes, potentially via a stretch-related process. We hypothesize that this cTnI release from viable cardiomyocytes is mediated by stimulation of stretch-responsive integrins.

Purpose: We characterized the release kinetics of cardiac troponin I and T in relation to lactate dehydrogenase (LDH) from cardiomyocytes before and after the transition from reversible to irreversible cell damage.

促凋亡基因代表成员 Bax，能够编码 α、β、γ、δ、ε、σ 共 6 种 Bax 蛋白亚型。 Bax 基因编码的具有生物学活性的 Baxα （21 kD），是 Bax 基因在细胞中发挥促凋亡作用的主要表达形式。

2007年10月2日 · It is demonstrated that intact cTnI can be released from viable cardiomyocytes by stimulation of stretch-responsive integrins, despite the ability of active MMP2 to degrade cTNI in vitro. Cardiac troponin in ischemic cardiomyocytes: intracellular decrease …

2009年4月5日 · In this review we focus on the utility of troponin in heart failure where this biomarker has emerged as an independent predictor of prognosis providing information beyond clinical assessment and measurement of b-type natriuretic peptides.

2008年4月1日 · Elevated cardiac troponin-I (cTnI) levels have been demonstrated in serum of patients without acute coronary syndromes, potentially via a stretch-related process. We hypothesize that this cTnI...

Elevated levels of cardiac troponin (cTn) indicate underlying heart disease and is known to predict adverse events in multiple conditions. Its role in atrial fibrillation (AF) in the acute setting is still not conclusive. We aimed to assess the prognostic value of c-Tn in patients with AF admitted to an emergency department (ED).

M. H. M. Hessel & D. E. Atsma & E. J. M. van der Valk & W. H. Bax & M. J. Schalij & A. van der Laarse Received: 27 June 2007 /Revised: 8 September 2007 /Accepted: 11 September 2007 / Published...

There is significant evidence about the association between the absolute value of elevated cardiac troponin levels with the prognosis of patients with chest pain. However, it is well-known that elevated cardiac troponin levels may occur in situations other than acute coronary syndromes, as it happens with atrial fibrillation.

2020年3月2日 · Here we show that BAX is rate-limiting in doxorubicin-induced cardiomyopathy and identify a small-molecule BAX inhibitor that blocks both apoptosis and necrosis to prevent this syndrome. By...