Vesicle-associated membrane protein 1 (VAMP1) is a protein that in humans is encoded by the VAMP1 gene. [5][6] Synaptobrevins /VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.

2024年12月25日 · VAMP1 (Vesicle Associated Membrane Protein 1) is a Protein Coding gene. Diseases associated with VAMP1 include Spastic Ataxia 1, Autosomal Dominant and Myasthenic Syndrome, Congenital, 25, Presynaptic. Among its related pathways are Uptake and actions of bacterial toxins and Infectious disease.

该基因编码的蛋白质是囊泡相关膜蛋白 (VAMP) /synaptobrevin 家族的成员。 该基因的突变与常染色体显性痉挛性共济失调 1 相关。 已描述了多种可变剪接变体，但尚未定义某些变体的全长性质。

囊泡 SNARE 蛋白 VAMP（也称 synaptobrevin）在细胞膜上结合 SNARE 蛋白 syntaxin 1 和 SNAP25，从而引导囊泡进行融合 (B)。 Munc18-1 结合单体 syntaxin 1 和 SNARE 复合体，并协助复合体组装。 共伴侣分子蛋白 complexin 和钙结合蛋白 synaptotagmin 1 (SYT1) 结合 SNARE 蛋白，形成紧密的复合体，从而聚集脂膜 (C)。 在突触前神经元中的动作电位打开电压门控钙通道时，钙离子结合 SYT1，并让 SYT1 与 SNARE 复合体和质膜相互作用，从而进行膜融合并将 …

One clone encodes VAMP-1 (vesicle-associated membrane protein 1), a nervous-system-specific protein of 120 amino acids whose primary sequence can be divided into three domains: a proline-rich amino terminus, a highly charged internal region, and a hydrophobic carboxyl-terminal domain that is predicted to comprise a membrane anchor.

Vesicle associated membrane proteins (VAMPs) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion. VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neurotransmitter release.

Screening of a library derived from primary human endothelial cells revealed a novel human isoform of vesicle-associated membrane protein-1 (VAMP-1), a protein involved in the targeting and/or fusion of transport vesicles to their target membrane.

VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy.

One clone encodes VAMP-1 (vesicle- associated membrane protein 1), a nervous-system-specific protein of 120 amino acids whose primary sequence can be divided into three domains: a proline-rich amino terminus, a highly charged internal region, and a hydrophobic carboxyl- terminal domain that is predicted to comprise a membrane anchor.

This report identifies vesicle-associated membrane protein 1 (VAMP1), which encodes a critical protein for synaptic exocytosis, as the responsible gene fora dominantly inherited spastic ataxia; multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion