Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene. [5] This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations.

2024年12月25日 · VAV3 (Vav Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with VAV3 include Osteopetrosis and Prostate Cancer. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and p75 NTR receptor-mediated signalling.

2025年2月8日 · VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma. VAV3 overexpression could be a useful marker for predicting the outcomes of CRC patients and that VAV3 targeting represents a potential modality for treating CRC; discrete and different functions of VAV3.1 in metastasis and tumorigenesis are conceivable.

2023年8月1日 · Available studies demonstrated that VAV3 promoted cell proliferation, epithelial-mesenchymal transition (EMT), colony formation, cell cycle, survival, migration and invasion, and suppressed cell apoptosis.

VAV 蛋白是 Rho 家族 GTP 酶的鸟嘌呤核苷酸交换因子 (GEF) ，可激活导致肌动蛋白细胞骨架重排和转录改变的通路。 该基因产物作为 GEF 优先用于 RhoG、RhoA，并在较小程度上作为 RAC1，并且它与这些 GTP 酶的无核苷酸状态最大限度地相关联。 已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2008 年 7 月] This gene is a member of the VAV gene family.

Vav 基因家族是受酪氨酸激酶调控的一组基因, 其主要功能是作为鸟嘌呤核苷酸交换因子在细胞调控中发挥作用 [10 - 12]. Vav 基因家族包括3个成员, 即 Vav1、Vav2、Vav3 基因 [13 - 15]. 其中 Vav1 基因位于人染色体19p13.3, 全长84.7 kb, 包括27个外显子, 编码的蛋白包括790个氨基酸, 能够调整细胞骨架, 调控T、B淋巴细胞的功能 [16, 17].

人类癌症中 vav3 水平较高，表明它可能在癌症进展中具有致癌作用。 现有研究表明，VAV3 促进细胞增殖、上皮间质转化 (EMT)、集落形成、细胞周期、存活、迁移和侵袭，并抑制细胞凋亡。

Vav3作为Vav家族蛋白的成员之一，由8个结构域组成，其结构的复杂性赋予其功能的多样性.它可通过调节Rho家族不同成员的活性参与对MAPK、PI3K-Akt、NF-κB等信号转导通路的调控，在维持细胞形态、细胞黏附、血管生成、免疫功能的调节和细胞分化等过程中发挥重要 ...

Vav家族蛋白是Rho家族GTPase的鸟嘌呤核苷酸转移因子.Vav3作为Vav家族蛋白的成员之一,由8个结构域组成,其结构的复杂性赋予其功能的多样性.它可通过调节Rho家族不同成员的活性参与对MAPK、PI3K-Akt、NF-κB等信号转导通路的调控,在维持细胞形态、细胞黏附、血管生成 ...

The higher levels of VAV3 in human cancers proposed that it may have an oncogenic role in cancer progression. Available studies demonstrated that VAV3 promoted cell proliferation, epithelial-mesenchymal transition (EMT), colony formation, cell cycle, survival, migration and invasion, and suppressed cell apoptosis.