Here, we found that angiopoietin-1 (Angpt1), a vascular maturation factor, is highly and specifically expressed in atrial myocardium during heart development. Loss of myocardial Angpt1 in mouse embryo led to severe impairment in atrial chamber morphogenesis.

2012年6月12日 · Versican (Vcan)/proteoglycan (PG)-M is a large chondroitin sulfate proteoglycan which forms a proteoglycan/hyaluronan (HA) aggregate in the extracellular matrix (ECM). We tried to generate the Vcan knockout mice by a conventional method, which resulted in mutant mice VcanΔ3/Δ3 whose Vcan lacks the A subdomain of the G1 domain.

2024年12月2日 · Classical monocytes (My.6) exhibited higher CD14, VCAN, and LYZ expression but lower FCGR3A expression, whereas non-classical monocytes (My.5) exhibited lower CD14 expression but higher FCGR3A ...

2021年3月5日 · Vcan proteolysis is mediated by ADAMTS enzymes, which cleave within the GAGβ domain, altering the biological properties of Vcan and releasing a neoepitope sequence (DPEEAE) termed versikine.

为了探究 心脏再生作用机制， 中国医学科学院阜外医院 聂宇教授与胡盛寿院士团队合作在研究团队在 Circulation（IF 37.8/Q1） 上发表题为 Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair 的研究性论文。 作者确定 Versican（Vcan） 是一种 心肌成纤维细胞 （cFB）来源的细胞外基质（ECM）成分，在新生儿心肌损伤后上调，促进 心肌细胞增殖。 条件敲除心脏成纤维细胞 中的Vcan会降低心肌细胞增殖， 损害新生儿心脏再生。 在成年小鼠心肌梗死后心肌内 …

2024年12月25日 · VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Disease. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Integrin Pathway.

2019年10月24日 · Versican (VCAN) proteolysis and the accumulation of VCAN fragments occur in many developmental and disease processes, affecting extracellular matrix (ECM) structure and cell phenotype.

2024年2月18日 · 为了探究 心脏再生作用机制， 中国医学科学院阜外医院 聂宇教授与胡盛寿院士团队合作在研究团队在 Circulation（IF 37.8/Q1） 上发表题为 Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair 的研究性论文。 作者确定 Versican（Vcan） 是一种 心肌成纤维细胞（cFB）来源的细胞外基质（ECM）成分，在新生儿心肌损伤后上调，促进心肌细胞增殖。 条件敲除心脏成纤维细胞 中的Vcan会降低心肌细胞增殖， 损害新生儿心脏再生。 在成年小鼠心 …

2022年7月7日 · We propose that the interplay between VCAN and VCAN–matrikines provides crucial survival, differentiation, and activation cues wherever tissue architecture is forged or altered, whether in the embryo or in the adult organism.

The ATRIA, CHADS 2, and CHA 2 DS 2 -VASc risk scores for the prediction of ischemic stroke in AF perform modestly, with the ATRIA risk score performing best. This study underlines the fact that the performance of low-, moderate-, and high-risk point score thresholds is sensitive to absolute population stroke rates.