Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene. [5][6] Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa.

2024年12月25日 · VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Disease. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Integrin Pathway.

The VCAN gene provides instructions for making a protein called versican. Versican is a type of protein known as a proteoglycan, which means it has several sugar molecules attached to it. Versican is found in the extracellular matrix of many different tissues and organs.

2025年1月4日 · This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and ...

2013年4月8日 · The versican gene encodes 4 extracellular matrix (ECM) isoforms that differ in the presence or length of a central glycosaminoglycan (GAG)-binding region. These proteins regulate cell adhesion, differentiation, and survival, in addition to cell proliferation and migration and ECM assembly (review by Wight (2002)).

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate p roteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and ...

To gain insight into the pathophysiology of vitreoretinal degeneration, the clinical course of three family members with Versican Vitreoretinopathy (VVR) is described, and a canonical splice site mutation in the gene encoding for versican (VCAN) ...

Wagner syndrome (WS) is an autosomal dominant vitreoretinopathy affecting various ocular features and is caused by mutations in the canonical splice sites of the VCAN gene, which encodes the large chondroitin sulfate proteoglycan, versican. We report the identification of novel splice acceptor and donor-site mutations (c.4004−1G>C and c.9265 ...

Low FOXA2/high VCAN levels mediate the tumor-promoting effects of miR-590-3p. The intronic VCAN mutation removes an MMP cleavage site, which alters versican structure and results in abnormal vitreous modeling. Disruption of a versican protein network may underlie clinicopathologic disease features and point to targeted therapies.

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and ...