2022年5月10日 · Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. They share the same structural domains at both N- and C-termini. The N-terminal G1 domain binds hyaluronan (HA), forms an HA-rich matrix, and regulates HA-mediated signaling.

2021年11月19日 · The main canonical components of PNNs, namely aggrecan (ACAN), neurocan (NCAN), versican (VCAN), phosphacan (PTPRZ1), brevican (BCAN), and tenascin-R (TNR), were highly enriched in OPCs, in ...

2018年4月12日 · Perineuronal nets (PNNs) are extracellular matrix structures surrounding neuronal sub-populations throughout the central nervous system, regulating plasticity. Enzymatically...

2024年12月25日 · VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Disease. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Integrin Pathway.

Perineuronal nets (PNNs) are a condensed, mesh-like form of ECM composed of hyaluronan, chondroitin sulfate proteoglycans (CSPGs: aggrecan, brevican, neurocan, versican, and phosphacan), link proteins (such as hyaluronan and proteoglycan link protein 1 [HAPLN1]), and tenascins (Fig. 1) (Fawcett et al., 2019).

2023年11月4日 · 该研究通过单细胞 RNA 测序和液相色谱 - 质谱联用分析，鉴定了心脏中一种可以促进心肌细胞增殖的调控因子 versican，并进一步揭示了 versican 在促进内源性心肌细胞增殖和心肌修复中的作用及机制，为临床上治疗心肌损伤提供了新的研究角度及潜在治疗策略。 这一研究是聂宇教授团队 2020 年在 Circulation 杂志发表“ gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration ”以来的系列工作之一，进一步从细胞外基质角度阐明了心肌组织微环境在 …

人类 Fras1 的突变是造成弗雷泽综合征的原因，该综合征偶尔会在患者中观察到脑畸形和精神障碍。在Fras1缺陷小鼠的皮层和皮层下区域发现 PNN 的 ECM 杂乱无章，表现出许多行为缺陷，包括受损的以自我为中心的空间记忆和异常的嗅觉学习和记忆。 Wegrzyn 等人。

2020年10月19日 · Childhood and adolescence are marked by the protracted formation of perineuronal nets (PNNs), which are essential in orchestrating the closure of developmental windows of cortical plasticity by regulating the functional integration of parvalbumin interneurons (PV) into neuronal circuits.

2019年11月24日 · Two forms of condensed hyaluronan-based ECM are found along the axon: the axon initial segment (AIS) domain of the perineuronal net (PNN) and the node of Ranvier (Fawcett et al. 2019). At the node of Ranvier, the myelin sheath is interrupted, and a few micrometers of the axonal membrane are directly exposed to the extracellular fluid.

2018年3月7日 · CSPGs also are important in synapse stabilization and maturation, mainly as components of perineuronal nets (PNNs), the specialized matrices that surround neurons and their dendrites in the CNS. ACAN expression is upregulated postnatally during PNN formation, while NCAN, VCAN and phosphacan/PTPRZ1 are all components of PNNs [72, 73].