
钙通道 - 维基百科,自由的百科全书
钙通道 (英語: Calcium channel,台湾极少数时亦称为 鈣徑)是选择性通透 Ca 2+ 的 离子通道,有时也是 电压依赖性钙通道 (VDCC (英语:Voltage-dependent calcium channel))的同义词 [1],而另外一种钙通道是 配体门控性钙通道 (LGCC (英语:Ligand-gated ion channel))。 [2] 下列表格阐述了2种钙通道的控性、 基因 、部位和功能。 平滑肌 和 心肌 [3]。 延长 心肌细胞 中的 动作电位 时间。 [3] 钙通道阻滞剂 可用于治疗 高血壓。 ^ F Striggow,BE Ehrlich. …
Voltage-gated calcium channel - Wikipedia
Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g. muscle, glial cells, neurons) with a permeability to the calcium ion Ca 2+. [1][2] These channels are slightly permeable to sodium ions, so they are also called...
综述解析系列︱突触前钙离子通道 (上) - 知乎 - 知乎专栏
电压门控钙离子通道 (Voltage-gated Ca2+ channels, 简称 Cav)在突触前膜的囊泡融合及神经递质的释放过程中扮演了重要角色。 这些离子通道的活性以及在突触前膜活性区域的分布数量调控着突触传递的时序以及强度。 先进的检测手段让我们能够清晰的观察到电压门控钙离子通道如何调节突触前膜的活动。
【科普文章-VGCC(一)】带你快速了解电压门控钙通道蛋白与 …
2022年1月13日 · 电压门控钙通道 (Voltage-Gated Calcium Channel,VGCC) 是跨膜离子通道蛋白家族的一员,其通道的开闭受到膜电位变化的控制。 VGCC 的生理功能为介导 Ca2+ 内流,响应胞膜去极化,并在许多不同类型的细胞中调节细胞的收缩、分泌、神经传输和基因表达等。 其活动对于将细胞表面的电信号与细胞内的生理事件耦合是至关重要的 [1]。 ->高电压激活通道(HVA):膜去极化电位较大时,受响应开启。 ->低电压激活通道(LVA):膜电位变化较小 …
电压门控钙通道 - 全球百科
电压门控钙通道 (VGCC),也称为电压依赖性钙通道 (VDCCs),是在可兴奋细胞(如肌肉、神经胶质细胞、神经元等)的膜中发现的一组电压门控离子通道。 对钙离子Ca2+具有渗透性。 这些通道对钠离子有轻微的渗透性,因此也被称为Ca2+-Na+通道,但它们对钙的渗透性是正常生理条件下对钠的渗透性的1000倍左右。 在生理或静息膜电位下,VGCCs通常是关闭的。 它们在去极化的膜电位下被激活(即:打开),这是... 电压 门控 钙 通道 (VGCC),也称为电压依赖性钙通道 …
Voltage-Dependent Calcium Channel - ScienceDirect Topics
Voltage-dependent calcium channels are channels that play a crucial role in neuronal signaling and synaptic transmission. Their functional changes can lead to various human disorders, both genetic and autoimmune, affecting neurotransmitter release at synapses. You might find these chapters and articles relevant to this topic.
Structure of human voltage-dependent calcium channel (VDCC) …
1997年12月1日 · In excitable and endocrine organs, calcium influxes through the voltage-dependent calcium channel (VDCC), composed of four (α1, α2, β, and δ) subunits.
Voltage-Dependent Calcium Channel - ScienceDirect Topics
Voltage-dependent calcium channels (VDCCs) regulate entry of extracellular calcium into electrically excitable cells, which initiates excitation coupling to crucial processes including neurotransmitter release, secretion, contraction and transcription [8].
Modulators of voltage-dependent calcium channels for the
Voltage-dependent Ca(2+) channels (VDCCs) play important roles in physiological functions and pathological processes of the nervous system. Given that the precise regulation of Ca(2+) signaling is important for neuronal processes such as action potential generation, transmitter release, and synaptic plasticity, alterations in Ca(2+) current through VDCCs affect the functions of neurons and ...
Voltage-Dependent Calcium Channel - ScienceDirect Topics
Voltage-dependent calcium channels (VDCC) are multi-subunit complexes comprizing 4 to 5 protein subunits. Their single membrane-spanning pore-forming subunit mediates calcium influx in response to membrane depolarization in excitable and non-excitable cells.
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