We investigated the clinical significance of a vascular growth pattern of hepatocellular carcinoma (HCC), the vessels that encapsulate tumor clusters (VETC), previously linked to HCC metastatic dissemination. VETC was assessed in a large multi-institutional cohort of 541 resected HCCs from Italy, Ko …

近期，我校生命科学学院庄诗美教授课题组在国际肝病学知名杂志Hepatology上发表题为“Vessels That Encapsulate Tumor Clusters (VETC) Pattern Is a Predictor of Sorafenib Benefit in Patients with Hepatocellular Carcinoma”的研究论文，并被推荐为杂志当期封面论文。该论文首次发现肝癌 …

2023年8月1日 · Vessels that encapsulate tumour clusters (VETC) is a novel and prevalent histologic pattern seen in HCC. VETC-positive HCCs form under the influence of angiopoietin 2 and metastasise via an invasion-independent mechanism where tumour clusters directly embolise into the bloodstream.

VETC, both an old and a new concept of pathological subclass of HCC, is a unique approach to considering HCC behavior and metastasis. The key to further clarifying molecular mechanisms of VETC in HCC will be the ability to distinguish it from Macro-T pathological subtype, which does not have encapsulating vessels.

Sorafenib is the most recommended first-line systemic therapy for advanced hepatocellular carcinoma (HCC). Yet there is no clinically applied biomarker for predicting sorafenib response. We have demonstrated that a vascular pattern, named VETC (Vessels that Encapsulate Tumor Clusters), facilitates t …

2023年9月9日 · 根据世界卫生组织标准，h/e染色用于评估hcc分级、组织类型，以及肿瘤内淋巴细胞的聚集；cd34染色用于评估vetc的存在，使用5%的临界值来定义vetc ...

2025年1月1日 · VETC (ves sel that encapsulate tumor cluster) is a peculiar vascular phenotype observed in hepatocellular carcinoma (HCC), associated with distant metastases and poor outcome. VETC has been linked to the Tie2/Ang2 axis and is characterized by lymphocytes poor (cold) tumor microenvironment (TME).

Based on histological examination on serial HCC sections and three-dimensional reconstruction, we found a novel and prevalent vascular pattern, vessels that encapsulated tumor clusters (VETC) and formed cobweb-like networks. The presence of VETC (VETC+) predicted higher metastasis and recurrence rates of HCC.

目前，研究发现一种新的血管转移模式—肿瘤包绕型血管（VETC），不依赖经典的上皮-间质转化转移方式，其转移程度更高，预后更差，给HCC患者的精准治疗带来更大的挑战。 故笔者总结VETC模式在HCC中研究现状、作用机制及临床意义，旨在为HCC的临床与基础研究提供参考。 Early metastasis is a significant cause of postoperative recurrence and high mortality of hepatocellular carcinoma (HCC).

2022年4月12日 · 随着对 HCC 的进一步研究，2015 年，中山大学生命科学学院庄诗美教授团队，首次发现一种独立于 EMT 促进HCC 转移的新血管模式—肿瘤包绕型血管（vessels that encapsulate tumor clusters pattern，VETC）的转移（图 1） [5] 。