2022年7月1日 · In this paper, we review the most recent studies on VGF gene structure, transcriptional regulation, protein processing, expression distribution, and potential receptors. We also discuss the latest research on the neuroendocrine effects of …

VGF and VGF-derived peptides have been repeatedly identified in well-powered and well-designed multi-omic studies as dysregulated in neurodegenerative and psychiatric diseases. New therapeutics is urgently needed for these devastating and costly diseases, as are new biomarkers to improve disease diagnosis and mechanistic understanding.

2021年10月27日 · In this review, we summarize recent studies that identify the physiological roles of VGF and VGF-derived peptides, their dysregulation in and potential use as neurodegenerative and psychiatric disease biomarkers and novel therapeutic targets.

从参与阿尔茨海默病发病机制的 537 个基因列表中，vgf 被阿尔茨海默病加速药物合作伙伴关系强调为最受关注的潜在治疗靶点。与对照组相比，阿尔茨海默病患者的脑组织和脑脊液样本中 vgf 水平持续降低，其水平与疾病严重程度和阿尔茨海默病病理学相关。

vgf 神经生长因子诱导型： 该基因在神经内分泌细胞亚群中特异性表达，并被神经生长因子上调。 该基因的结构组织与大鼠基因相似，翻译区和非翻译区均显示出与大鼠基因高度的序列相似性。

2021年10月27日 · VGF and VGF-derived peptides have been repeatedly identified in well-powered and well-designed multi-omic studies as dysregulated in neurodegenerative and psychiatric diseases. New therapeutics is urgently needed for these devastating and costly diseases, as are new biomarkers to improve disease diagnosis and mechanistic understanding.

2017年11月21日 · Here, we show that VGF (non-acronymic), which is robustly regulated by BDNF/TrkB signaling, is downregulated in hippocampus (male/female) and upregulated in nucleus accumbens (NAc) (male) in...

2015年2月1日 · VGF peptides have been associated with a number of neuroendocrine roles, and in this review, we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction, and cognition.

Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry. This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor.

2011年12月1日 · We review the VGF (non acronymic) multifunctional peptide precursor. VGF mRNA is regulated by neurotrophins, synaptic activity, homeostatic and other stimuli. Heterogeneous VGF peptides are variably produced in neuro/endocrine organs. Some are active on homeostasis, reproduction or neuronal activity. Others are found in cerebro-spinal fluid ...