vgf 神经生长因子诱导型： 该基因在神经内分泌细胞亚群中特异性表达，并被神经生长因子上调。 该基因的结构组织与大鼠基因相似，翻译区和非翻译区均显示出与大鼠基因高度的序列相似性。

2022年7月1日 · These studies revealed a novel active neuroendocrine regulatory polypeptide, VGF nerve growth factor inducible (VGF). VGF is an NGF-inducible transcript in PC12 cells, and this non-acronymic name is accepted because the identified clone was selected from plate “V” of a PC12 cDNA library [7].

2024年12月25日 · VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include Vaccinia and Pheochromocytoma. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Signaling by NTRKs.

In this review, we summarize recent studies that identify the physiological roles of VGF and VGF-derived peptides, their dysregulation in and potential use as neurodegenerative and psychiatric disease biomarkers and novel therapeutic targets.

2011年12月1日 · We review the VGF (non acronymic) multifunctional peptide precursor. VGF mRNA is regulated by neurotrophins, synaptic activity, homeostatic and other stimuli. Heterogeneous VGF peptides are variably produced in neuro/endocrine organs. Some are active on homeostasis, reproduction or neuronal activity. Others are found in cerebro-spinal fluid ...

2017年11月21日 · Here, we show that VGF (non-acronymic), which is robustly regulated by BDNF/TrkB signaling, is downregulated in hippocampus (male/female) and upregulated in nucleus accumbens (NAc) (male) in...

从参与阿尔茨海默病发病机制的 537 个基因列表中，VGF 被阿尔茨海默病加速药物合作伙伴关系强调为最受关注的潜在治疗靶点。 与对照组相比，阿尔茨海默病患者的脑组织和脑脊液样本中 VGF 水平持续降低，其水平与疾病严重程度和阿尔茨海默病病理学相关。 在大脑中，VGF 以多种功能性 VGF 衍生肽的形式存在。 全长人 VGF1-615 在受调节的分泌途径中通过激素原转化酶和其他蛋白酶进行蛋白水解加工，产生至少 12 种活性 VGF 衍生肽。 在细胞和动物模型中，这些 …

VGF (nonacronymic) is a granin-like neuropeptide precursor whose expression is robustly regulated by neuronal lesions and growth factors. 9, 34, 55 VGF-derived peptides have a functional role in several disorders including obesity, dementia, depression, and pain. This review focuses on the role of VGF in pain pathways.

神经内分泌调节多肽VGF（nerve growth factor inducible）最早发现于神经生长因子对PC12细胞的快速诱导作用。它选择性地分布在神经元和许多神经内分泌组织中。本文回顾了有关VGF基因结构、转录调控、蛋白质加工、分布和潜在受体的最新文献。

Targeted deletion of VGF, a secreted neuronal and endocrine peptide precursor, produces lean, hypermetabolic, and infertile mice that are resistant to diet-, lesion-, and genetically-induced obesity and diabetes. Previous studies suggest that VGF ...