homology with beta-amyloid, particularly matching a VGGVV C-terminus pentapeptide 81 (Fig 1). The VGGVG epitope has been used to label beta-amyloid1-40 in extracellular neurofibrillary tangles 93.

In this figure, panel A represents standards, i.e., two synthetic peptides standards, VGGVV and VGGVVIA, which were co-injected. Panels B and C represent analyses of brain amyloid from two different patients, with different ratios of Aβ40:Aβ42.

2023年5月17日 · We identified that the di-glycine region of Aβ 36–40 (sequence VGGVV) exhibits the most profound change in response to cholesterol compared with other segments, explaining how the presence of cholesterol affects the γ-secretase cutting site. This study provides spectroscopic evidence showing how cholesterol modulates the structure of the ...

2023年5月17日 · We identified that the di-glycine region of Aβ 36-40 (sequence VGGVV) exhibits the most profound change in response to cholesterol compared with other segments, explaining how the presence of cholesterol affects the γ-secretase cutting site. This study provides spectroscopic evidence showing how cholesterol modulates the structure of the APP ...

In order to characterize the ensemble of Aβ 1–40 peptide structures in the membrane environment, we have investigated the structure of monomeric Aβ 1–40 peptide (DAEFR HDSGY EVHHQ KLVFF AEDVG SNKGA IIGLM VGGVV) in an implicit membrane environment using replica-exchange molecular dynamics (REMD) simulation. 60 The structures are described ...

consensus VGGVV sequence, suggesting that Alzheimer’s disease may also be related to viral mimicry. HSV-1 and other Herpes viral infections have been

2010年10月1日 · The vascular or parenquimal origin of senile plaques was determined using specific polyclonal antibodies reactive for epitopes VGGVV or GVVIA of the Aβ40 and Aβ42, respectively. We found in the gray matter of SAD and FAD samples a sub-set of amyloid plaques positive for IDE which partially co-localized with Aβ42 and Aβ40 deposits ( Fig. 4 A ...

2007年5月2日 · Aggregation of the amyloid peptides, Aβ40 and Aβ42, is known to be involved in the pathology of Alzheimer's disease (AD). Here we investigate the relationship between peptide aggregation and cell surface binding of three forms of Aβ (Aβ40, Aβ42, and an Aβ mutant).

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Aβ(1–42) peptide (sequence DAEFR-HDSGY-EVHHQ-KLVFF-AEDVG-SNKGA-IIGLM-VGGVV-IA) was chemically synthesized by an Applied Biosystems (ABI) model 433A automated peptide synthesizer (Life Technologies, Carlsbad, CA) with Fmoc protected 13 C- and 15 N-labeled amino acids (Sigma Aldrich, St. Louis, MO, and Cambridge Isotope Laboratories, Andover ...