Development and comparison of three 89Zr-labeled anti …
Both anti-CLDN18.2 VHH-ABD and anti-CLDN18.2 VHH-Fc can be efficiently and stably radiolabeled with 89 Zr for noninvasive imaging and quantification of CLDN18.2 expression in …
抗体药物研究新热点 l 双特异纳米抗体 - 知乎 - 知乎专栏
纳米抗体（Nanobody）是由比利时科学家于1993年在自然杂志中首次报道，只包含一重链可变区VHH，得益于小分子量（15KDa）、与人源VHs高度同源以及稳定性高等优势，近年来纳米抗 …
纳米抗体VHH/单域抗体：结构、优缺点及制备平台详解-义翘神州
纳米抗体（nanobody, Nb）是一种人工设计的抗体分子，又称为单域抗体（single-domain antibodies, sdAbs）、VHH抗体或camelid抗体，是发现于羊驼、单峰驼等驼科以及鲨鱼、鳐鱼 …
Development and Characterization of the [177Lu]Lu-Labeled Anti …
2025年3月15日 · In preclinical studies, [177 Lu]Lu-anti-CDH17 VHH-ABD demonstrated substantial antitumor efficacy with manageable toxicity, offering promising clinical potential as …
Development and Characterization of the - PubMed
2025年3月15日 · In preclinical studies, [177 Lu]Lu-anti-CDH17 VHH-ABD demonstrated substantial antitumor efficacy with manageable toxicity, offering promising clinical potential as …
Nanobody-Targeted Conditional Antimicrobial Therapeutics
2025年3月5日 · Here, we report the development and optimization of nanobody (VHH)-targeted conditional antimicrobial therapeutics for the conditional delivery of therapeutic peptide and …
开发和比较三种 89Zr 标记的抗 CLDN18.2 抗体以无创评估 …
抗 cldn18.2 vhh-abd 和抗 cldn18.2 vhh-fc 都可以用 89 zr 高效稳定地进行放射性标记，用于胃癌中 cldn18.2 表达的无创成像和定量，其中 89 zr-抗 cldn18。 2 vhh-abd 似乎是平衡肿瘤摄取和肝 …
Study of 89Zr-labeled recombinant antibody VHH-Fc for …
2022年8月1日 · In this study, we used three self-designed and commercially constructed anti-CLDN18.2 antibodies, VHH, VHH-ABD and VHH-Fc, in animal model and human body PET …
Development and comparison of three 89Zr-labeled anti …
2022年3月26日 · Both anti-CLDN18.2 VHH-ABD and anti-CLDN18.2 VHH-Fc can be efficiently and stably radiolabeled with 89Zr for noninvasive imaging and quantification of CLDN18.2 …
A Schematic representation of the primary structures of anti …
Methods Screening from anti-CLDN18.2 nanobody library, we constructed three antibodies, anti-CLDN18.2 VHH (recombinant sin... [...] Purpose: Positron emission tomography (PET) with …