Viral vector platforms within the gene therapy landscape
2021年2月8日 · To review the viral vector-based gene therapy landscape, we focus on these three highly regarded vector platforms and describe mechanisms of action and their roles in treating human...
Viral Vectors in Gene Therapy - PMC - PubMed Central (PMC)
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine.
Viral vector platforms within the gene therapy landscape
2021年2月8日 · To review the viral vector-based gene therapy landscape, we focus on these three highly regarded vector platforms and describe mechanisms of action and their roles in treating human disease. Throughout its 40-year history, the field of gene therapy has been marked by many transitions.
Vectors in gene therapy - Wikipedia
Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
Viral Vector-Based Gene Therapy - PubMed
2023年4月23日 · With decades of development, viral vector-based gene therapies have achieved promising clinical outcomes. Currently, the three key vector strategies are based on adeno-associated viruses, adenoviruses, and lentiviruses.
Adeno-associated virus as a delivery vector for gene therapy of …
2024年4月3日 · Viral-based gene therapy utilizes viruses as gene delivery vectors, including AAV, adenovirus, retrovirus, lentivirus, and herpes simplex virus. Non-viral-based gene therapy includes antisense...
Viral Vectors in Gene Therapy: Where Do We Stand in 2023?
2023年3月7日 · Viral vectors have been used for a broad spectrum of gene therapy for both acute and chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor, toxic, suicide and immunostimulatory genes, such as …
Viral and Non-viral Vectors | Lentiviral, Adenoviral & AAV - Gene Therapy
When using any virus (adenovirus, adeno-associated virus, or lentivirus) as the basis of a vector for gene therapy, scientists use only certain parts or components of the virus, and they do not use parts of the gene that cause an infection or allow for the virus to replicate itself within the body.
FDA Approves First Gene Therapy for Treatment of Aromatic L …
2024年11月14日 · The U.S. Food and Drug Administration approved Kebilidi (eladocagene exuparvovec-tneq), an adeno-associated virus vector-based gene therapy indicated for the treatment of adult and pediatric ...
Using Viral Vectors for Gene Therapy Treatments | Pfizer
2023年6月13日 · Viruses such as adeno-associated viruses (AAVs) are commonly used as vectors for gene therapy given their ability to deliver genes to non-dividing cells where the gene has a long-term therapeutic impact.