2022年2月1日 · Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission.

In the Th1-oriented memory response to influenza, we have tested the contributions of two potential mechanisms for this diversity: variable expression of cytokines by a uniform population during activation, or different stable subsets that consistently expressed subsets of the Th1 cytokine pattern.

Manipulation of the Th1/Th2 balance has demonstrated therapeutic capabilities by reconstituting Th1 cells for the prevention of CD8+ T-cell decay thereby enhancing CD8+ T-cell activity and the control of infection of lymphocytic choriomeningitis virus (LCMV) .

Little is known about how predominantly cellular (Th1 type) versus humoral (Th2 type) immune responses influence SARS-CoV-2 dynamics, including infectivity and disease course. Methods: We generated knock-in (KI) mice expressing human ACE2 (hACE2) and/or human TMPRSS2 (hTMPRSS2) on Th1-biased (C57BL/6; B6) and Th2-biased (BALB/c) genetic ...

2023年6月30日 · Little is known about how predominantly cellular (Th1 type) versus humoral (Th2 type) immune responses influence SARS-CoV-2 dynamics, including infectivity and disease course. We generated knock-in (KI) mice expressing human ACE2 (hACE2) and/or human TMPRSS2 (hTMPRSS2) on Th1-biased (C57BL/6; B6) and …

Th1 cells are mainly involved in promoting the eradication of virus-infected cells and intracellular pathogens within peripheral tissues. Th1 cells are defined by the transcription factors T-bet, and they express IFNγ as their signature cytokine.

2001年8月1日 · Th1 and Th2 cells amplify and shape the immune responses that mediate protection of the host during infectious disease. In both types of Th response the activated DCs in the spleen and lymph nodes play the major role in presenting Ag to the naive CD4 + Th cell. Ligand interactions with PRRs expressed on DCs are an important branch point . If ...

2023年8月11日 · Conditional ablation of Arg1 in CD4 + T cells accelerated both virus-specific T helper 1 (Th1) effector responses and its resolution, resulting in efficient viral clearance and reduced lung pathology.

Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission.

2020年12月22日 · The variant with lower S protein expression levels was genetically stable and induced high levels of effective Th1-biased antibody and T cell responses in mice after two immunizations. In addition to neutralizing IgG antibody responses in a protective range, multifunctional CD8 + and CD4 + T cell responses with S protein-specific killing ...