2021年6月30日 · In this study, we propose an alternative anastomosis technique. It uses the biodegradable tissue adhesive VIVO and an individualized expandable stent, similar to stents in coronary angioplasty,...

2024年3月20日 · Simulated surgical application in human tissue ex vivo and in a porcine model of thecal sac injury in vivo demonstrated superior adhesion under increasing pressure. Biocompatibility was demonstrated over 4 weeks in a rat craniotomy model. This study supports the potential of this tough bioadhesive hydrogel for dural repair after neurosurgery.

2021年6月14日 · We demonstrate the glue’s robust performance in vitro and in vivo for cosmetic and hemostasis applications and accelerated wound healing by comparison to surgical wound closures. Strong...

2023年1月24日 · Herein, we identified a natural biological adhesive from snail secretion, analyzed its composition and structure, elucidated the mechanism of its gelatinization, evaluated in vitro adhesion...

2023年8月16日 · On the basis of the results of in vitro biocompatibility, ex vivo tissue adhesion, and in vivo hemostasis and wound closure, the HA-PEG hydrogel could achieve rapid wound closure and hemostasis, promote wound healing, and relieve inflammation at the wound sites.

2024年12月18日 · The ex vivo sealing ability of Hep@Gel hydrogels was determined with the burst pressure tests on porcine corneal tissues as shown in Fig. 3 (P and Q). Briefly, a 3-mm full-thickness punch injury was made in the cornea, and 30 μl of the hydrogels or fibrin glue was used to seal the corneal perforation.

2025年3月14日 · Magnesium phosphate-based mineral bone cements exhibit high biocompatibility, particularly for the use as bone substitutes. In combination with calcium ions and phytic acid as liquid components, these cements demonstrate adhesive properties and potentially represent a promising new type of bone glue.

2022年1月11日 · Injectable hydrogels show high potential for in vivo biomedical applications owing to their distinctive mode of administration into the human body. In this study, we propose a material design strategy for developing a multifunctional injectable hydrogel with good adhesiveness, stretchability, and bioresorbability.

2021年6月30日 · Overall, 120 porcine coronary vessels were analyzed in an ex vivo model and were examined for their mechanical (n = 20 per cohort) and hydrostatic strength (n = 20 per cohort). Anastomoses were made using the novel VIVO adhesive with an additional intraluminal nitinol stent and was compared to interrupted suture anastomosis and to native vessels.

VIVO* is a polyurethane-based surgical sealant, designed as an adjunct to standard methods of achieving hemostasis in vascular reconstructions by mechanically sealing areas of leakage. The delivery system for VIVO is a two-chamber syringe. VIVO’s formulation allows for use in a wet environment (e.g. in areas of bleeding).