2024年12月25日 · VSIG4 (V-Set And Immunoglobulin Domain Containing 4) is a Protein Coding gene. Diseases associated with VSIG4 include Adiponectin Deficiency and Atypical Hemolytic-Uremic Syndrome. Among its related pathways is Complement cascade. Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.

可溶性VSIG4-Fc融合蛋白被报道可预防实验性自身免疫性关节炎 [1]、狼疮肾炎、皮肤病 [2]和肝炎 [3]的发生；最近也有报道VSIG4的表达与抗肿瘤免疫的调节有关，如肺癌 [4]和高级别胶质瘤 [5]等。 百奥赛图开发了 B-hVSIG4 mice，助推相关药物的药效验证。 基本信息. 基因功能介绍. Vsig4（V-set和免疫球蛋白结构域包含4）编码一个V-set和免疫球蛋白结构域包含的蛋白，在结构上与免疫调节蛋白的B7家族相关。 在肝脏、树突状细胞、中性粒细胞和静息巨噬细胞中高水 …

2022年12月22日 · VSIG4（V-set and immunoglobulin domain containing 4）是最新鉴定的B7家族共刺激分子，又称补体受体Ig超家族分子（CRIg），或免疫球蛋白超家族蛋白39（Z39Ig）。人和鼠VSIG4基因均定位于X染色体的Xq12，属于I型跨膜蛋白。

We have identified a previously unknown function for B7 family-related protein V-set and Ig domain-containing 4 (VSIG4). In vitro experiments using VSIG4-Ig fusion molecules showed that VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production.

2017年11月6日 · Here we show that V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein that is expressed by resting macrophages, inhibits macrophage activation in response to...

We demonstrate here that macrophages lacking V-set and immunoglobulin domain–containing 4 (Vsig4) exhibit significant increases in Nlrp3 and Il-1β transcription, caspase-1 activation, pyroptosis, and interleukin-1β (IL-1β) secretion in response to NLRP3 inflammasome stimuli. VSIG4 interacts with MS4A6D in the formation of a surface ...

V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene. [5] This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses.

2023年1月28日 · V-set and immunoglobulin domain containing 4 (VSIG4), a type I transmembrane receptor exclusively expressed in a subset of tissue-resident macrophages, plays a pivotal role in clearing C3-opsonized pathogens and their byproducts from the circulation. VSIG4 maintains immune homeostasis by suppressing …

2025年2月7日 · V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4 + TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. However, the mechanism how VSIG4 + TAMs mediate immune evasion in aggressive cancers have not been fully elucidated.

2023年1月28日 · V-set and immunoglobulin domain containing 4 (VSIG4), a type I transmembrane receptor exclusively expressed in a subset of tissue-resident macrophages, plays a pivotal role in clearing C3-opsonized pathogens and their byproducts from the circulation.