2022年9月7日 · Esophageal squamous cell cancer (ESCC) is the major pathologic type of esophageal cancer in Asian population. To systematically evaluate the mutational features...

2024年5月2日 · Detecting early-stage esophageal squamous cell carcinoma (ESCC) and precancerous lesions is critical for improving survival. Here, we conduct whole-genome bisulfite...

2020年5月12日 · This study provides the most comprehensive characterization of ESCC genomes, to date, using deep WGS in a large Chinese patient cohort with clinical follow-up data.

Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma (CCGD-ESCC) is a comprehensive database for searching the associations of single nucleotide polymorphisms (SNPs) with the risk of ESCC (genome-wide association studies, GWASs), patients’ survival (Survival GWAS) or gene expression (expression quantitative trait loci, eQTLs).

ESCC-WGS 流程是想对 全基因组测序 （Whole Genome Sequencing, WGS）原始数据进行分析和处 理的，分析的内容包括： SNV and indel calling； Copy number analysis and LOH identification（更新中）； structure variants detections（后续）； 后续的更多分析。

2024年5月8日 · 从配对的WGBS和原发性肿瘤的全基因组测序（WGS）数据中鉴定出ESCC的DMR和CNV，并从之前的队列ESCC基因组和表观基因组图谱（ECGEA）中匹配了155例ESCC病例的邻近癌旁组织。

2022年1月21日 · To explore the potential therapeutic targets of ESCC, we integrated and reanalyzed the mutation data of WGS (whole genome sequencing) or WES (whole exome sequencing) from a total of 1,145 samples in 7 large ESCC cohorts, including 270 ESCC gene expression data.

In this study, we performed WGS, WGBS, RNA sequencing, and small RNA sequencing on tumor tissues as well as matched adjacent non-neoplastic tissues from ESCC patients to discover potential molecular subgroups.

2024年4月2日 · Whole-genome sequencing (WGS) is by far the most effective technology to fully characterize the molecular profile of mtDNA. However, tens of thousands of coverages of mtDNA in the regular WGS data result in extremely high redundancy and heterogeneity.

2019年4月11日 · Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome...