2024年12月25日 · WIF1 (WNT Inhibitory Factor 1) is a Protein Coding gene. Diseases associated with WIF1 include Colorectal Cancer and Squamous Cell Papilloma. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by WNT. An important paralog of this gene is CD93.

WIF1 is a lipid -binding protein that binds to Wnt proteins and prevents them from triggering signalling. [6][7][8] WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities.

这种蛋白质包含一个 Wnt 抑制因子 (WIF) 结构域和五个表皮生长因子 (EGF) 样结构域，并且被认为与中胚层分割有关。 该基因作为肿瘤抑制基因发挥作用，并已被发现在各种癌症中被表观遗传沉默。

2025年2月8日 · WIF-1 silencing due to promoter hypermethylation is an important mechanism underlying aberrant activation of the Wnt signaling pathway in carcinogenesis of the digestive organs; Modification of the Wnt-signaling pathway are often associated with development of tumor and may play a significant role in carcinogenesis [review]

2024年9月11日 · WIF-1 Protein, Human (HEK293, His) 是重组的 WIF-1 蛋白，由 HEK293 表达，带有 C-6*His 标签。 WIF-1 Protein, Human (HEK293, His) 全长 351 个氨基酸，分子量约为 42-48 kDa。 生物活性： 1.以抑制MC3T3-E1小鼠前成骨细胞Wnt-3a诱导的碱性磷酸酶产生的能力来衡量，在20 ng/ mL 重组人Wnt-3a存在下，该作用的ED50为0.1022-0.1136 μg/mL，对应的比活为8802.8169-9784.7358单位/mg。

WIF-1是Wnt信号通路上的拮抗物之一,可以阻断Wnt的经典通路和非经典通路.目前在人类多种肿瘤的研究发现WIF-1表达异常.WIF-1 (Wnt inhibitory factor-1),sFRP (Frizzled related protein)和CER (Cerberus)属于Wnt拮抗物家族,通过直接与Wnt蛋白相连从而阻止Wnt与受体蛋白复合物相连,使细胞质中的β-catenin由于磷酸化而不能积累,进而阻断了经典通路和非经典通路.WIF-1可能与中胚层的发生以及肿瘤细胞的生长分化有关.Wnt家族其他成员已经被证实与早期冠心病,Ⅱ型糖尿病,肥 …

WIF-1 protein critically binds to WNT protein, inhibits its activity and regulates the WNT signaling pathway. In addition to its inhibitory role, WIF-1 may also contribute to mesoderm segmentation, implicating its role in embryonic development.

Wif-1通过直接与Wnt蛋白相连，从而阻止Wnt与受体蛋白复合物相连，使细胞质中的β-catenin由于磷酸化而不能积累，进而阻断了经典和非经典Wnt通路。 该转基因小鼠可用于Wif-1对心血管系统的生物学功能相关研究。

2014年5月20日 · WIF-1 是 WNT 信号通路的生理抑制剂，用于预防因 WNT 信号通路激活而导致的致癌作用。 WIF 结构域的结构已知具有与 WNT 分子相互作用的结合位点，而其 EGF 样结构域的功能仍然未知。 方法：研究 WIF-1 在 EGFR 信号通路中的潜在参与，在硅蛋白 - 蛋白质对接之间... 11124 背景：致癌作用是癌基因和肿瘤抑制基因在细胞水平上的协调表达和抑制。 表皮生长因子受体 (EGFR) 和无翼和整合位点生长因子 (WNT) 信号通路在细胞发育中的早期参与引起了研 …

WIF1 (Wnt inhibitory factor 1) is a secreted protein that binds to Wnt proteins and inhibits their activity (1). It contains an N-terminal WIF domain and five EGF-like repeats (2). The WIF1 ortholog in Drosophila, Shifted, is required for Hedgehog stability and diffusion (3,4).