Sodium hydride is the chemical compound with the empirical formula Na H. This alkali metal hydride is primarily used as a strong yet combustible base in organic synthesis. NaH is a saline (salt-like) hydride, composed of Na + and H − ions, in contrast to molecular hydrides such as borane, silane, germane, ammonia, and methane.

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.

2023年10月14日 · A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Explore the Efficacy and Safety of Intravenous Nerinetide (NA-1) Initiated by Paramedics in the Field for Suspected Stroke Within Three Hours of Symptom Onset

钠氢交换蛋白1 (NHE-1)是一种细胞膜蛋白，主要分布于人和哺乳动物的心肌细胞中，调控细胞内外离子交换。 目前越来越多的基础研究证实，NHE-1在多种心血管疾病中，尤其是心力衰竭、心肌肥厚、冠心病等的发生、发展中起着重要作用。 虽然近十余年来，多项针对NHE-1抑制剂的临床研究结果差强人意，但我们应从中归纳总结、辩证分析，以期寻找到其真正的临床意义。 引用本文: 马嘉琪, 陈章炜, 钱菊英. 钠氢交换蛋白1及其抑制剂的研究进展 [J] . 中国心血管杂志, 2019, 24 …

During myocardial ischemia-reperfusion, NHE1 catalyzes increased uptake of intracellular Na +, which in turn leads to Ca 2+ overload and subsequently myocardial injury. Numerous preclinical research has shown that NHE1 is involved in cardiac hypertrophy and heart failure, but the exact molecular mechanisms remain elusive.

2018年3月22日 · NA-1, also known as Tat-NR2B9c, disrupts the NMDAR-PSD95-nNOS complex, dissociating NMDARs from downstream neurotoxic signaling, without blocking normal synaptic function of NMDARs or calcium...

We used a computer-generated randomisation sequence to allocate patients to receive an intravenous infusion of either NA-1 or saline control at the end of their endovascular procedure (1:1; stratified by site, age, and aneurysm status). Both patients and investigators were masked to treatment allocation.

Identify the structure and function of the cell and the integumentary, musculoskeletal, nervous, cardiovascular, respiratory, digestive, urinary, reproductive, endocrine, and immune systems. Describe the nurse aide’s role in the provision of care for a resident with cancer.

2020年2月24日 · Nerinetide（NA-1）是一种神经保护剂，可干扰突触后密度蛋白95（PSD-95），通过终止细胞内NO自由基的产生来实现，在临床前缺血性脑卒中模型中可减少脑缺血再灌注的梗死面积，并改善其功能预后。 急性缺血性脑卒中（AIS）患者进行EVT治疗现在可以有效实现缺血再灌注。 该研究旨在确定静脉注射新型神经肽（NA-1，2.6mg/kg）对选择用于EVT的AIS患者的疗效和安全性。 2. 研究方法. 先前的数据表明，阿替普酶激活纤溶酶，可裂解Nerinetide …

NA-1, also known as Tat-NR2B9c, disrupts the NMDAR-PSD95-nNOS complex, dissociating NMDARs from downstream neurotoxic signaling, without blocking normal synaptic function of NMDARs or calcium influx.