2024年12月25日 · WNK1 (WNK Lysine Deficient Protein Kinase 1) is a Protein Coding gene. Diseases associated with WNK1 include Pseudohypoaldosteronism, Type Iic and Neuropathy, Hereditary Sensory And Autonomic, Type Iia. Among its related pathways are Ion channel transport and Apoptotic Pathways in Synovial Fibroblasts.

wnk1是一种广泛表达的 丝氨酸苏氨酸激酶 ，高渗透胁迫会使得wnk1从均匀分布转变为点状分布，但是这些点状信号的作用尚不清楚。 通过活体成像，作者们发现瞬时表达大鼠的WNK1在高渗条件下会与下游磷酸化 激活效应 因子共定位，这说明细胞中斑点的形成可能 ...

WNK1 (with no lysine (K)) is a widely expressed serine/threonine protein kinase. The role of this kinase was first described in the kidney where it dynamically controls ion channels that regulate changes in cell volume.

The WNK1 gene provides instructions for making multiple versions (isoforms) of the WNK1 protein. The different WNK1 isoforms are important in several functions in the body, including blood pressure regulation and pain sensation.

WNK (lysine deficient protein kinase 1), also known as WNK1, is an enzyme that is encoded by the WNK1 gene. [5][6][7][8][9] WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. [5][6][7][9] The predominant role of WNK1 is the regulation of cation-Cl − cotransporters (CCCs) such as the sodium chloride cotr...

2025年2月8日 · WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells. WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly. Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.

2022年10月31日 · WNK1 is a molecular crowding sensor that undergoes cell shrinkage-dependent phase separation to restore cell volume. This study provides a clear link between the intrinsically disordered region-mediated phase separation of a protein and cell physiology.

2022年9月19日 · WNK kinases are involved in the regulation of tumor growth, metastasis and angiogenesis through complex mechanisms. WNK-SPAK/OSR1 signaling is a potential target for cancer treatment. What are the...

2020年4月14日 · WNK1 and WNK4 activate the NaCl cotransporter (NCC) at the distal convoluted tubule through oxidative stress-responsive gene 1 (OSR1)/Ste20-related proline–alanine-rich kinase (SPAK),...

2025年2月8日 · WNK1 is a dual modulator of TGFbeta-Smad signaling pathways; WNK1 is a physiologically relevant target of insulin signaling through PI3K and Akt/PKB and functions as a negative regulator of insulin-stimulated mitogenesis