Serine/threonine protein kinase WNK4 also known as With No lysine (K) protein kinase 4 (WNK4), is an enzyme that in humans is encoded by the WNK4 gene. [5] Missense mutations cause a genetic form of pseudohypoaldosteronism type 2, also called Gordon syndrome or Familial Hyperkalemic Hypertension.

2024年12月25日 · WNK4 (WNK Lysine Deficient Protein Kinase 4) is a Protein Coding gene. Diseases associated with WNK4 include Pseudohypoaldosteronism, Type Iib and Pseudohypoaldosteronism. Among its related pathways are Ion channel transport and Transport of inorganic cations/anions and amino acids/oligopeptides.

WNK4 is the smallest member of the mammalian WNK kinase family, with a molecular mass of ∼134 kDa. Roughly 35% of the primary sequence of WNK4 is predicted to have a secondary structure, whereas the remaining 65% is predicted to be disordered (Fig. 1 A). Around one-half of those disordered regions contain low-complexity sequences.

2021年3月1日 · With no lysine kinase-4 (WNK4) belongs to a serine-threonine kinase family characterized by the atypical positioning of its catalytic lysine. Despite the fact that WNK4 has been found in many tissues, the majority of its study has revolved around its function in the kidney, specifically as a positiv …

2022年9月19日 · Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals.

The WNK4 gene provides instructions for making a protein that plays a role in blood pressure regulation by helping control the amount of sodium and potassium in the body.

2025年2月8日 · WNK4 promotes sodium chloride co-transporter targeting to the lysosome for degradation via a mechanism involving sortilin. WNK4 suppresses plasma membrane expression of the thiazide-sensitive NaCl cotransporter (NCC), diverting it from the trans-Golgi network to the lysosome via an intracellular route.

In this study, we identified a novel role of WNK4-ERK1/2 signaling in the regulation of NCC. WNK4 increases the phosphorylation of ERK1/2 in mDCT cells, whereas WNK4 PHA II-causing mutants, E562K and R1185C, lose the ability to phosphorylate ERK1/2.

Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals.

The WNK4 gene provides instructions for making a protein that plays a role in blood pressure regulation by helping control the amount of sodium and potassium in the body.