Serine/threonine protein kinase WNK4 also known as With No lysine (K) protein kinase 4 (WNK4), is an enzyme that in humans is encoded by the WNK4 gene. [5] Missense mutations cause a …

2024年12月25日 · WNK4 (WNK Lysine Deficient Protein Kinase 4) is a Protein Coding gene. Diseases associated with WNK4 include Pseudohypoaldosteronism, Type Iib and …

WNK4 is the smallest member of the mammalian WNK kinase family, with a molecular mass of ∼134 kDa. Roughly 35% of the primary sequence of WNK4 is predicted to have a secondary …

2021年3月1日 · With no lysine kinase-4 (WNK4) belongs to a serine-threonine kinase family characterized by the atypical positioning of its catalytic lysine. Despite the fact that WNK4 has …

2022年9月19日 · Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …

The WNK4 gene provides instructions for making a protein that plays a role in blood pressure regulation by helping control the amount of sodium and potassium in the body.

2025年2月8日 · WNK4 promotes sodium chloride co-transporter targeting to the lysosome for degradation via a mechanism involving sortilin. WNK4 suppresses plasma membrane …

In this study, we identified a novel role of WNK4-ERK1/2 signaling in the regulation of NCC. WNK4 increases the phosphorylation of ERK1/2 in mDCT cells, whereas WNK4 PHA II …

Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members, WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in mammals.

The WNK4 gene provides instructions for making a protein that plays a role in blood pressure regulation by helping control the amount of sodium and potassium in the body.