Systemic lupus erythematosus (SLE) is the quintessential autoimmune disease. A complex interaction of impaired apoptotic clearance, upregulation of innate and adaptive immune system, complement activation, immune complexes, and tissue inflammation culminates in a self-sustained autoimmune process.

2023年8月4日 · Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement. Several immunopathogenic pathways play a role in the development of SLE.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. It is multifactorial and involves epigenetic, genetic, ecological, and environmental factors. Primarily it leads to activation of both innate and ...

2024年4月17日 · Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterised by the presence of autoantibodies towards nuclear antigens, immune complex deposition, and chronic inflammation at classic target organs such as skin, joints, and kidneys.

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune rheumatic disease in which disease flares are interspersed with episodes of remission. In contrast to organ specific autoimmune diseases, SLE comprises a constellation of signs and symptoms that can affect multiple organ systems.

2023年8月4日 · Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement.

Penyakit SLE (systemic lupus erythematosus) ditandai dengan pembentukan antibodi terhadap beragam zat penghasil antibodi dan kompleks imun yang bervariasi. Dengan kata lain, penyakit ini adalah penyakit dimana sistem kekebalan tubuh menjadi hiperdefensif, menyerang sel, organ, dan jaringan tubuhnya sendiri seolah-olah penyakit yang perlu ...

Dokumen tersebut membahas tentang faktor-faktor penyebab Lupus Eritematosus Sistemik (SLE) yang meliputi faktor genetik, lingkungan seperti paparan ultraviolet, hormonal, obat-obatan, infeksi, dan stres berlebihan.

SLICC Classification Criteria 2012 [1] Requirements: >4 of the following criteria (at least 1 clinical and 1 laboratory) OR biopsy proven lupus nephritis with positive ANA or Anti-dsDNA. Organ system affected: Undiagnosed. Flare. Drug Induced Lupus. Risk Factors for Infection [2] Studies.

Since the European League Against Rheumatism/American College of Rheumatology 2019 classification criteria for systemic lupus erythematosus (SLE) were published, they were externally validated by groups worldwide. In particular, the new criteria worked well also in East Asian and pediatric cohorts.