Presence of invasive WPOI is associated with advanced T stage, poor differentiation, PNI, greater depth of invasion, and higher chances of nodal metastasis. WPOI is associated with poor DFS, treatment intensification in early stage disease with WPOI type IV & V may improve survival.

2020年12月29日 · Worst pattern of invasion (WPOI) (AJCC: Cancer Staging [Accessed 21 September 2018], CAP: Protocol for the Examination of Specimens from Patients with Cancers of the Lip and Oral Cavity [Accessed 29 December 2020]): Validated outcome predictor for oral cavity squamous carcinoma patients in multivariate analysis

The histologic risk assessment score was composed of the worst pattern of invasion (WPOI), lymphocytic host response (LHR), and perineural invasion (PNI), as previously described 6 (Figure 2A–C). High-risk WPOI was marked by small tumor islands <15 cells and satellite tumor(s) located at least 1 mm away from the main tumor or the nearest ...

2024年3月1日 · This study analyses the prognostic significance of worst pattern of invasion (WPOI) in a unique population of pathologically proven node-negative early-stage oral tongue cancer patients to see if the WPOI is a prognostic marker …

2023年1月4日 · The patients with a high WPOI score (defined as <15 cells in an invasive island, single cells, or satellite tumor cells) were associated with higher mortality compared to those with a low WPOI score (defined as pushing borders, finger-like and cohesive invasion) .

2018年6月1日 · Univariate and multivariate analyses revealed that a tumor budding score ≥4 is a significant independent predictive factor for the occurrence of occult neck metastasis, which in turn is a significant independent prognostic factor.

2023年10月18日 · WPOI is predictive of disease free survival in oral cancer. WPOI is described as five patterns - but generally divided into two (prognostic) groups: WPOI 1-4: better prognosis. WPOI 5: poor prognosis. Definition of WPOI 5. WPOI 5 is defined as >=1 mm normal tissue between two tumour masses. See also. Tumour budding. Spread through air spaces.

2023年10月23日 · In a multicenter study involving 311 patients with OSCC, the WPOI was found to be an independent prognostic factor for the OS and DFS rates, indicating its potential value in risk stratification and treatment decisions. 3 Furthermore, one study demonstrated that patients with a WPOI of 5 had a worse 5-year OS rate than those with a WPOI of 1 to ...

2018年4月19日 · All three invasive patterns, the mode of invasion, WPOI, and tumor budding, were found to be significant predictors of 5-year disease-free survival (p<0.01, p = 0.03, and p<0.01, respectively) as well as lymphovascular invasion (p = …

Results: Depth of invasion (P = 0.008), WPOI- 4 and 5 (P = 0.033), sCNS (<5 cells) at tumor interface (P = 0.010), high bud count (≥3 buds/40 × hpf) (P = 0.021) and poor LHR (P = 0.019) correlated significantly with poor disease-free survival on univariate analysis.