2024年12月25日 · WT1 is a tumor suppressor gene associated with the development of Wilms' Tumor, from which it was named. Mutations in exon 7 and 9 of WT1 have been recurrently …

Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p. [5][6][7][8] This gene encodes a transcription factor that contains four zinc …

2019年4月9日 · 1、WT1 的结构和功能. WT1（Wilm's tumor gene）基因定位于11p13，是最早发现与Wilm's肿瘤发生、发展有关的基因[1]，全长约50kb，有10个外显子，转录产物长约3kb， …

提示wt1基因表达量可作为aml患者的预后评估指标，其表达显著降低或升高可辅助预测aml患者的缓解或复发。 wt1基因表达是aml不良预后和较短总生存期的独立预测因子，且是早期复发的 …

2007年3月15日 · In this review, we explore the literature supporting both views of WT1 in human cancer and in particular human leukemias. To understand the mechanism by which WT1 can …

2020年4月30日 · WT1 disorder is characterized by congenital/infantile or childhood onset of steroid-resistant nephrotic syndrome (SRNS), a progressive glomerulopathy that does not …

Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly expressed in leukemia and various types of solid …

2014年12月16日 · We show here that all these cell types frequently express the Wilms’ tumour suppressor Wt1, which transcriptionally controls expression of Pecam-1 (CD31) and c-kit …

WT-1（Wilms tumor protein），由11号染色体上的WT1基因编码，在正常泌尿生殖道的发育中起重要作用，在wilm氏瘤中突变失活从而导致该肿瘤发生而得名。 其在细胞内可与p53结合从而 …

The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 …