2024年12月25日 · WT1 is a tumor suppressor gene associated with the development of Wilms' Tumor, from which it was named. Mutations in exon 7 and 9 of WT1 have been recurrently identified in acute myeloid leukemia and associated with …

Wilms tumor protein (WT33) is a protein that in humans is encoded by the WT1 gene on chromosome 11p. [5][6][7][8] This gene encodes a transcription factor that contains four zinc finger motifs at the C-terminus and a proline / glutamine -rich …

2019年4月9日 · 1、WT1 的结构和功能. WT1（Wilm's tumor gene）基因定位于11p13，是最早发现与Wilm's肿瘤发生、发展有关的基因[1]，全长约50kb，有10个外显子，转录产物长约3kb，编码一个相对分子质量约（52~54）X10^3的，具有激活和抑制双重功能的转录调控蛋白。

提示wt1基因表达量可作为aml患者的预后评估指标，其表达显著降低或升高可辅助预测aml患者的缓解或复发。 wt1基因表达是aml不良预后和较短总生存期的独立预测因子，且是早期复发的预测指标 。

2007年3月15日 · In this review, we explore the literature supporting both views of WT1 in human cancer and in particular human leukemias. To understand the mechanism by which WT1 can do this, we will also...

2020年4月30日 · WT1 disorder is characterized by congenital/infantile or childhood onset of steroid-resistant nephrotic syndrome (SRNS), a progressive glomerulopathy that does not respond to standard steroid therapy.

Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell growth and differentiation. The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for …

2014年12月16日 · We show here that all these cell types frequently express the Wilms’ tumour suppressor Wt1, which transcriptionally controls expression of Pecam-1 (CD31) and c-kit (CD117).

WT-1（Wilms tumor protein），由11号染色体上的WT1基因编码，在正常泌尿生殖道的发育中起重要作用，在wilm氏瘤中突变失活从而导致该肿瘤发生而得名。 其在细胞内可与p53结合从而发挥其抑癌作用。

The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males) before birth. After birth, WT1 protein activity is limited to a structure known as the glomerulus, which filters blood through the …