NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded …

2024年12月25日 · WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with WWP2 include Spondyloepiphyseal Dysplasia, …

编码的蛋白质包含四个 WW 结构域，可能在多个过程中发挥作用，包括软骨形成和通过与 Smad 蛋白和肿瘤抑制因子 PTEN 的相互作用调节致癌信号通路。 已观察到该基因编码多种亚型的 …

2022年11月30日 · Here we focus on WWP2, an E3 ubiquitin ligase that acts as a positive genetic regulator of human and murine cardiac fibrosis, and show that myeloid specific deletion of …

2025年2月9日 · WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway. WWP2 overexpression inhibits the antitumor …

2025年1月4日 · WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.

2024年4月1日 · In this review, we describe the multiple roles of WWP2, an E3 ubiquitin ligase with unique and important functions in regulating a wide range of biological processes, including …

WWP2 is an E3 ubiquitin ligase that belongs to the NEDD4-like protein family, which is involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation …

WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently …

WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, …