In oncology, the Warburg effect (/ ˈ v ɑːr b ʊər ɡ /) is the observation that most cancers use aerobic glycolysis and lactic acid fermentation for energy generation rather than the mechanisms used by non-cancerous cells. [1]

2021年1月13日 · New research is revealing the mechanisms regulating the Warburg effect, the balance between oxidation and glycolysis of glucose in cancer cells.

2021年5月21日 · Demetrios et al. found that, in the Warburg effect, the flux of glucose to lactate is up to 100 times faster than through the TCA cycle resulting in similar amounts of ATP production over the same time .

2021年1月15日 · In the 1920s, German chemist Otto Warburg discovered that cancer cells don’t metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient.

2024年11月19日 · Discover the Warburg Effect, a hallmark of cancer metabolism, where cancer cells rely on glycolysis for energy. Explore its discovery, mechanisms, and impact on modern cancer research and treatment. Skip to the content

2023年10月31日 · How does aerobic glycolysis, inefficient in producing ATP, confer a growth advantage to cancer cells? A new evaluation of a large set of literature findings covering the Warburg effect and its yeast counterpart, the Crabtree effect, led to an innovative working hypothesis presented here.

The Warburg Effect refers to the preference of cancer cells to convert glucose into lactate through glycolysis rather than utilizing oxidative phosphorylation, even when oxygen is readily available. This phenomenon was first observed by Otto Warburg in the early 20th century.

2024年3月8日 · The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy.

2019年9月27日 · This review describes the Warburg effect from a historical perspective, how this fundamental finding on cancer metabolism was forgotten for several decades before re-emerging with the discovery of metabolic oncogenes and how the Warburg effect forms the basis of several therapeutic strategies in cancer currently used or in development.

The Warburg effect, also known as ‘aerobic’ glycolysis, describes the preference of cancer cells to favor glycolysis over oxidative phosphorylation for energy (adenosine triphosphate-ATP) production, despite having high amounts of oxygen and fully active mitochondria, a phenomenon first identified by Otto Warburg.