2020年5月12日 · To address how mouse Wdfy1 affects innate defense, we compared the cellular immune responses of wild-type (Wdfy1 +/+) mice and Wdfy1-KO (Wdfy1 −/−) mice against poly I:C and LPS. We first...

Here, we identify the WD repeat and FYVE-domain-containing protein WDFY1 as a crucial adaptor protein in the TLR3/4 signaling pathway. Overexpression of WDFY1 potentiates TLR3- and TLR4-mediated activation of NF-κB, interferon regulatory factor 3 (IRF3), and production of type I interferons and inflammatory cytokines.

2022年3月12日 · The mouse WD repeat and FYVE domain containing 1 (Wdfy1) gene is located in chromosome 1qC4 and spans over 73.7 kilobases. It encodes a protein of 410-amino acid protein that shares 97.8% amino acid sequence identity with the human WDFY1 protein.

2024年12月25日 · WDFY1 (WD Repeat And FYVE Domain Containing 1) is a Protein Coding gene. Diseases associated with WDFY1 include Rett Syndrome, Congenital Variant and Basan Syndrome. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol binding. An important paralog of this gene is WDFY2.

Here, we identify the WD repeat and FYVE-domain-containing protein WDFY1 as a crucial adaptor protein in the TLR3/4 signaling pathway. Overexpression of WDFY1 potentiates TLR3- and TLR4-mediated activation of NF-κB, interferon regulatory factor 3 (IRF3), and production of type I interferons and inflammatory cytokines.

2015年3月3日 · Here, we identify the WD repeat and FYVE ‐domain‐containing protein WDFY 1 as a crucial adaptor protein in the TLR 3/4 signaling pathway. Overexpression of WDFY 1 potentiates TLR 3‐ and TLR 4‐mediated activation of NF ‐κB, interferon regulatory factor 3 (IRF 3), and production of type I interferons and inflammatory cytokines.

该基因编码的蛋白是磷脂酰肌醇 3-磷酸结合蛋白，含有一个 FYVE 锌指结构域和多个 WD-40 重复结构域。 当外源表达时，它定位于早期内体。 诱变分析表明，这种内体定位是由 FYVE 结构域介导的。 [RefSeq 提供，2015 年 1 月] The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes.

2015年3月3日 · Is WDFY1 essential for stimulation of TLR3/4-driven immune activation in response to microbial pathogens? Is WDFY1 involved in mounting antimicrobial and inflammatory responses in vivo ? Collectively, this work contributes important new insights on how TLRs control the recruitment of adaptor proteins to achieve full immune activation in ...

These results suggest that mouse Wdfy1 is important for both Tlr3 signaling against double-stranded RNA and Tlr4 signaling against gram-negative bacteria in immune cells. We then performed...

Cell Mol Immunol. 2020 Sep;17 (9):1014-1016. doi: 10.1038/s41423-020-0461-4. Epub 2020 May 12. 1 State Key Laboratory of Virology, Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, 430072, China.