2024年5月1日 · Finally, PPIs have been associated with higher rates of acute interstitial nephritis and end-stage renal disease, so it may be prudent to wean off of them in patients at risk for chronic kidney disease progression.

Begin by taking your regular dose of OTC PPI medication every other day for 1-2 weeks as your symptom level allows. If symptoms exacerbate beyond a tolerable level, try taking a half dose daily for a few days, then wean back to a reduced dose every other day.

2025年2月19日 · There’s no single method for stopping a PPI. But there are three main strategies you can try, which may help prevent rebound symptoms. 1. Taper your PPI gradually. Many people assume that slowly cutting back on their PPI dose is better than stopping cold turkey. But one study found no significant difference between these strategies.

Finally, PPIs have been associated with higher rates of acute interstitial nephritis and endstage renal disease, so it may be - prudent to wean off of them in patients at risk for chronic kidney disease progression.

2022年2月16日 · Experts share 10 pieces of best practice advice highlighting specific clinical scenarios that call for discontinuing PPIs, and how to approach de-prescribing.

• In general, wean slowly by 50% or stop outright and use on-demand. • If reason for deprescribing is a serious adverse effect, consider weaning faster. • Provide advice to patient/carer on self-monitoring and what to do if symptoms re-occur.

JP It is reasonable to try to wean patients on long-term PPI therapy who have uncomplicated or nonerosive reflux disease (ie, no endoscopic evidence of severe esophagitis or strictures) down to the lowest effective PPI dose. For example, a patient on a twice-daily dose can go down to a once-daily dose.

2016年10月14日 · This raises an important question for clinicians who see patients with LPR: How do you assess whether a patient should be on PPIs on a long-term basis, and how do you wean them off of the medication if necessary?

2022年3月25日 · He usually recommends patients stay with one herbal remedy while weaning off PPIs. Kiefer, on the other hand, says patients can combine herbs. He suggests using anti-inflammatories such as chamomile or DGL plus melatonin during the medication tapering process.

2021年2月19日 · At Tampa Bay Reflux Center, we encourage all of our patients to take steps to wean themselves from PPIs and seek alternative treatment options like anti-reflux surgery, the only thing proven to effectively treat GERD long-term by correcting the LES and alleviating the symptoms of GERD. Here are some