Brain-derived neurotrophic factor - Wikipedia
Brain-derived neurotrophic factor (BDNF), or abrineurin, [5] is a protein [6] that, in humans, is encoded by the BDNF gene. [7] [8] BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5.
The Role of Brain-Derived Neurotrophic Factor (BDNF) in …
Brain-derived neurotrophic factor (BDNF) belongs to the family of neurotrophins, which are growth factors with trophic effects on neurons. BDNF is the most widely distributed neurotrophin in the central nervous system (CNS) and is highly expressed in the …
Frontiers | Brain-Derived Neurotrophic Factor: A Key Molecule …
2019年7月25日 · Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes related to learning and memory. The expression of BDNF is highly regulated, and can lead to great variability in BDNF levels in healthy subjects.
Brain-derived Neurotrophic Factor - PMC - PubMed Central (PMC)
Castrén E, Thoenen H, Lindholm D. Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus.
Brain-Derived Neurotropic Factor in Neurodegenerative Disorders
Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 …
Brain-derived neurotrophic factor | Neurology
2015年3月27日 · Brain-derived neurotrophic factor (BDNF) is the most ubiquitous and intensively studied member of the family of neurotrophins in the CNS. The transcriptional regulation of BDNF is complex and involves both epigenetic control and transcription factors.
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on ...
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF with neuronal maintenance, neuronal survival, plasticity, and neurotransmitter regulation.
Brain-Derived Neurotrophic Factor - an overview - ScienceDirect
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and it has emerged as a major regulator of synaptic plasticity, neuronal survival, and differentiation. Although widely expressed in the adult mammalian brain, BDNF is particularly abundant in the hippocampus and cerebral cortex ( Altar et al., 1997 ; Baquet et al ...
Brain-derived neurotrophic factor and its clinical implications
2015年12月10日 · Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It …
Brain Derived Neurotrophic Factor - an overview - ScienceDirect
Brain-derived neurotrophic factor (BDNF) is a secreted protein and a member of the neurotrophin family of growth factors that provide trophic support for neurons and encourage the growth and differentiation of new neurons and synapses.
Brain-Derived Neurotrophic Factor: A Key Molecule for Memory …
2019年8月7日 · Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes related to learning and memory. The expression of BDNF is highly regulated, and can lead to great variability in BDNF levels in healthy subjects.
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on ...
2018年8月17日 · Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF with neuronal maintenance, neuronal survival, plasticity, and …
Brain-Derived Neurotrophic Factor - an overview - ScienceDirect
Brain-derived neurotrophic factor (BDNF) is a secreted protein and a member of the neurotrophin family of growth factors that provide trophic support for neurons and encourage the growth and differentiation of new neurons and synapses.
BDNF: A Key Factor with Multipotent Impact on Brain Signaling …
2017年6月16日 · Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in the mammalian brain. Among its prominent functions, one can mention control of neuronal and glial development, neuroprotection, and modulation of both short- and long-lasting synaptic interactions, which are critical for ...
Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions
Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies over the last three decades have identified mature BDNF as a key regulator of neuronal …
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on ...
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF with neuronal maintenance, neuronal survival, plasticity, and neurotransmitter regulation.
Peripheral blood brain-derived neurotrophic factor in bipolar …
Peripheral blood brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in bipolar disorder, speculated to mirror alterations in brain expression of BDNF. The research area is rapidly evolving; however, recent investigations have yielded conflicting results with ...
Brain-derived neurotrophic factor and mental disorders - PMC
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades.
Brain-derived neurotrophic factor in diabetes mellitus: A …
2023年2月14日 · 1. Introduction. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that acts as a neurotransmitter modulator contributing in survival and plasticity of neurons as well as maintenance and growth of β cells of the pancreas [1,2].Diabetes mellitus (DM) is a major concern in healthcare worldwide, with high morbidity and mortality.
Brain-derived neurotrophic factor: a bridge between …
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as crucial mediator of neuronal plasticity, since it is abundant in brain regions particularly relevant for plasticity, but also because it shows a remarkable activity-dependent regulation of expression and secretion (Bramham and Messaoudi, 2005), suggesting that it might ...
Brain-Derived Neurotrophic Factor (BDNF): Novel Insights into ...
Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that now spans 35 years of research. While all neurotrophins share considerable overlap in sequence homology and their processing, BDNF has become the most widely studied neurotrophin because of its broad roles in …
Actions of Brain-Derived Neurotrophin Factor in the …
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the central nervous system (CNS). BDNF stimulates mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), phosphoinositide-3kinase (PI3K ...
Brain-derived neurotrophic factor rs6265 (Val66Met) single …
Brain-derived neurotrophic factor is the most prevalent member of the nerve growth factor family. Since its discovery in 1978, this enigmatic molecule has spawned more than 27,000 publications, most of which are focused on neurological disorders. Brain-derived neurotrophic factor is indispensable du …