‡ Between the end of the preceding pregnancy and the start of chemotherapy.

Below is a WHO prognostic score calculator to aid in clinical decision making for determining whether a patient should be assigned to single agent or multi-agent chemotherapy. Select the most advanced (right most) site of metastases identified on imaging.

2021年10月20日 · Gestational trophoblastic disease (GTD) arises from abnormal placenta and is composed of a spectrum of premalignant to malignant disorders. Changes in epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway.

2018年6月7日 · Gestational trophoblast disease (GTD) describes a set of diseases originating in placental tissue, specifically the chorionic villi and extravillous trophoblast. Other terms for this group include gestational trophoblastic neoplasia (GTN), and …

Gestational trophoblastic neoplasia (GTN) is staged by The American Joint Committee on Cancer (AJCC) and the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) based on...

While in the traditional WHO scoring system the GTN was divided into low-, medium- and high-risk groups, in the new system the GTN is stratified into two groups: (i) low-risk group (score ≤6) intimating single-agent chemotherapy; and (ii) high-risk group (score >6) mandating multi-agent chemotherapy. Risk is defined as the risk of developing ...

2016年12月12日 · Gestational trophoblastic disease (GTD) refers to a group of benign and malignant tumors that develop in the uterus from placental tissue. Pathogenesis of GTD is unique in that maternal tumors arise from gestational tissue that can have locally invasive or …

Background Actinomycin-D (Act-D) and Methotrexate (MTX) are both effective first-line agents for low-risk gestational trophoblastic neoplasia (LRGTN) with no consensus regarding which is more...

2024年9月25日 · Gestational trophoblastic neoplasia (GTN) is a rare form of cancer that is treated according to the World Health Organization (WHO) risk score, which predicts responsiveness to single-agent chemotherapy. Patients with WHO risk scores ≤6 have low-risk GTN, for which cure rates near 100%.

Low risk GTN is defined as persistent molar pregnancy with a WHO score lower than seven. The optimal chemotherapeutic regimen still remains controversial. Aim: The objectives of this study was to determine efficacy and safety of weekly intramuscular methotrexte in the treatment of low risk gestational trophoblastic neoplasia.