2011年6月6日 · We found that AMPK activation suppressed Wnt/β-catenin signals via diminished β-catenin levels. This crosstalk between AMPK and the Wnt/β-catenin signaling pathway may be important for understanding the effect of AMPK on osteoblast function in vitro and bone remodeling in vivo .

Biochemical, metabolomic, confocal microscopy and mouse genetics experiments all demonstrate coordinated activation of Wnt signaling, predominantly in neurons, and the ensuing induction of an overall aerobic glycolysis (Warburg-like phenomenon) and an altered TCA cycle in early epileptogenesis.

We now report that several “Wnt inhibitors” that allegedly target β-catenin actually function as mitochondrial proton uncouplers that independently activate AMPK and concomitantly inhibit Wnt signaling.

2024年6月20日 · An AMPK inhibitor accelerates activation of dormant follicles in murine in vitro-cultured ovaries, accompanied with an upregulation of Wnt and FOXO genes, phosphorylation of β-catenin, and ...

Our results indicate that HNF4α is a targetable oncoprotein in GC, is regulated by AMPK signalling through AMPKα and resides upstream of WNT signalling. HNF4α may regulate 'metabolic switch' characteristic of a general malignant phenotype and its target WNT5A has potential prognostic values.

2023年10月24日 · In this work, we found that LKB1/AMPK axis activation leads to the inhibition of Wnt/β-catenin through phosphorylation of USP10. Mechanism-wise, AMPK-phosphorylated USP10 shows higher potency to deubiquitinate/stabilize Axin1 and obtains stronger binding affinity to β-catenin for further phase separation, both of which lead to the degradation ...

2021年8月6日 · This split Warburg metabolic reprogramming triggers an inhibition of AMPK and subsequent activation of mTOR, which is a signature event of epileptogenesis. Interrogation of the mechanism with the metabolic inhibitor 2-deoxyglucose surprisingly demonstrated that Wnt signaling and the resulting metabolic reprogramming lies upstream of mTOR ...

WIF1 增加线粒体中的 ΔΨm 并下调线粒体自噬相关蛋白的表达，包括 Parkin、Pink1、LC3-II/LC3-I 比率、切割的半胱天冬酶 3 和 cyt-c，从而改善线粒体功能障碍。体内研究进一步证明了 WIF1 在 STZ 诱导的小鼠中的一致作用。总之，WIF1 通过下调 AMPK/mTOR 通路改善了 DR 中的线

AMPK 是重要的调节寿命通路，可有效调控细胞自噬和抑制mTor，其更类似于在恶劣情况下的适应性机制。 这篇Review详细介绍了如何AMPK信号通路，由复旦药学院Doctor candidate Freda翻译。 接下来的文章将会介绍，如何激活AMPK通路。 以下Enjoy： 请看正文. 摘要. 细胞需调整自身的能量供应和营养补给来维持代谢。 真核细胞已经进化出一套复杂的系统，即通过丝氨酸/苏氨酸激酶AMP-激活蛋白激酶复合物（AMPK，serine/threonine kinase AMP-activated protein …

2011年6月6日 · AMP-activated protein kinase (AMPK) is a key sensor of cellular energetic conditions. Recent studies suggest that AMPK affects osteoblast differentiation, although its role and mechanism are not fully understood. One of the most important signals in osteoblast differentiation is the Wnt/β-catenin pa …