2018年2月20日 · Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase (ERK) pathways play important roles in the tumorigenesis of many different types of cancer, most notably...

2018年2月20日 · Aberrant activation of the Wnt/β-catenin and RAS-extracellular signal-regulated kinase (ERK) pathways play important roles in the tumorigenesis of many different types of cancer, most notably colorectal cancer (CRC). Genes for these two pathways, such as adenomatous polyposis coli ( APC …

2023年11月10日 · Wnt 家族会与 Ras/Raf/MEK/ERK，TGFβ/Smad 等通路产生 Crosstalk，相互影响协作调控与细胞侵袭转移相关的基因，共同参与调解肿瘤细胞 EMT 过程。 还有 许多蛋白靶点通过参与调控 Wnt/β-catenin 而影响肿瘤细胞 EMT 过程 。

Wnt /β-catenin和RAS细胞外信号调节激酶（ERK）通路的异常激活在许多不同类型的癌症（尤其是结直肠癌（CRC））的肿瘤发生中起重要作用。 这两种途径的基因，如腺瘤性息肉病（APC）和KRAS，在人类CRC中经常发生突变，并分别参与肿瘤发生的发生和发展。

2021年4月16日 · Overall, we demonstrated that inhibiting the Wnt/β-catenin and RAS/ERK pathways by destabilizing β-catenin and RAS could be a therapeutic approach to overcome gemcitabine resistance in pancreatic cancer.

2018年5月1日 · In this review, we summarized the current understanding of cross-talk between Wnt/β-catenin and RAS/ERK pathways related with the synergism in the pathogenesis of CRC by APC and KRAS mutations, which are most frequently found in human CRC.

2007年5月15日 · Wnt/β-catenin signaling stimulates extracellular signal-regulated kinase (ERK) pathways through effects on Ras.

This work presents a simple mathematical model of EMT, specifically the roles played by four key proteins in the Wnt signaling pathway: Dishevelled (Dvl), E-cadherin, β-catenin, and Slug.

LED irradiation effects on the expression of molecules associated with the Wnt/β-catenin signaling and ERK pathway, hair stem cell markers, and various growth factors and cytokines in hORSCs were examined with real-time PCR and Western blot assay.

2005年1月15日 · The degree of Wnt3a-induced proliferation was reduced by β-catenin small interfering RNA (siRNA) and extracellular signal-regulated kinase (ERK) siRNA, indicating that both the ERK and Wnt/β-catenin pathways are involved in Wnt3a-induced proliferation.