Protein kinase C in Wnt signaling: implications in cancer ... - PubMed
PKC is one of the key targets of noncanonical Wnt signaling, particularly in the Wnt/Ca(2+) pathway. Recently, data have implicated components of noncanonical Wnt/Ca(2+) and …
Wnt/β-Catenin信号通路 - 知乎 - 知乎专栏
Wnt 配体是一种分泌型糖蛋白，可结合 Frizzled (卷曲）受体，然后与 LRP5/6 一起在细胞表面形成一个更大的复合体。 卷曲受体被 ZNRF3 和 RNF43 泛素化，二者的活性可通过 R-spondin 结 …
RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent ...
2010年1月29日 · Here we identify a specific mechanism of orphan nuclear receptor RORα-mediated inhibition of canonical Wnt signaling in colon cancer. Wnt5a/PKCα-dependent …
Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in …
2019年5月18日 · Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which are found in familial adenomatosis polyposis and in 80% of sporadic colorectal …
PKCδ is essential for Dishevelled function in a noncanonical Wnt ...
Protein kinase C (PKC) has been implicated in the Wnt signaling pathway; however, its molecular role is poorly understood. We identified novel genes encoding δ-type PKC in the Xenopus EST …
Wnt and calcium signaling: β-Catenin-independent pathways
2005年9月1日 · First, specific Wnt and frizzled homologs can activate calcium/calmodulin-dependent kinase II (CamKII) and protein kinase C (PKC) in a Wnt/calcium pathway. Second, …
Protein kinase C delta negatively modulates canonical Wnt ... - PubMed
The tumor suppressor Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers. Alterations in Protein kinase C (PKC) isozyme expression and aberrant regulation …
Unraveling Cancer’s Wnt Signaling: Dynamic Control through …
Persistent activation of Wnt signaling exerts diverse cancer characteristics, encompassing tumor initiation, tumor growth, cell senescence, cell death, differentiation, and metastasis. Here we …
Protein-kinase-C-mediated beta-catenin phosphorylation …
2006年11月15日 · Here we present small-molecule-based identification of protein kinase C (PKC)-mediated beta-catenin phosphorylation as a novel mechanism regulating the Wnt/beta …
Wnt5a through Noncanonical Wnt/JNK or Wnt/PKC Signaling
2014年3月21日 · In the noncanonical Wnt pathway, Wnt ligand such as Wnt5a induces calcium influx through Dvl, followed by the phosphorylation of the downstream Calmodulin-dependent …
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